Normalization of Mineral Ion Homeostasis by Dietary Means Prevents Hyperparathyroidism, Rickets, and Osteomalacia, But Not Alopecia in Vitamin D Receptor-Ablated Mice

October 1998 in “ Endocrinology ”

Y. C. Li

vitamin D receptor alopecia mineral ion homeostasis VDR deficiency

TLDR Diet can prevent bone issues but not hair loss in mice lacking vitamin D receptors.

The study investigated the effects of normalizing mineral ion levels through diet in vitamin D receptor (VDR)-ablated mice. It was found that this dietary intervention prevented secondary hyperparathyroidism, rickets, and osteomalacia by normalizing growth and serum ionized calcium levels. Despite these improvements, alopecia persisted in the VDR-ablated mice, indicating that the vitamin D receptor is essential for normal hair growth. This suggested that while mineral ion homeostasis could prevent certain bone-related conditions, it did not address hair loss associated with VDR deficiency.

View this study on academic.oup.com →

Discuss this study in the Community →

Research cited in this study

1 / 1 results

research Topographical and Developmental Studies on Target Sites of 1,25 (OH)₂ Vitamin D₃ in Skin

70 citations, November 1984 in “Cell & tissue research/Cell and tissue research”

Vitamin D3 affects cell differentiation in specific skin areas.

Similar Research

5 / 1000+ results

research Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice

1533 citations, October 2008 in “Endocrine reviews”

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

research Ligand-Independent Actions of Vitamin D Receptor

December 2017 in “Elsevier eBooks”

The vitamin D receptor helps maintain hair and bone health even without binding vitamin D.

research Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes

78 citations, November 2005 in “Endocrinology”

Hairless protein can block vitamin D activation in skin cells.

research Development and Progression of Alopecia in the Vitamin D Receptor Null Mouse

81 citations, January 2006 in “Journal of cellular physiology”

Mice without the vitamin D receptor gene lose hair due to disrupted hair follicle cycles.

research Deletion of DNA Binding Domain of the Vitamin D Receptor Abrogates Genomic and Nongenomic Functions of Vitamin D

277 citations, July 2002 in “Molecular Endocrinology”

Removing part of the vitamin D receptor stops vitamin D from working properly.

Normalization of Mineral Ion Homeostasis by Dietary Means Prevents Hyperparathyroidism, Rickets, and Osteomalacia, But Not Alopecia in Vitamin D Receptor-Ablated Mice

Research cited in this study

research Topographical and Developmental Studies on Target Sites of 1,25 (OH)₂ Vitamin D₃ in Skin

Related Community Posts Join

community Why do we get bald from evolutionary perspective

community Boys I am just a gonner. What on earth is my scalp even going through. Looks like world war 3. Pyril 3 months. Topical melitonin/progesterone/fin, dut, fin, oral min, laser trash, anus stimulation. Nothing. Donor area is decimated 😂.

community Been on Min and Fin for Years and I am Devastated.

community Female, 27 years old, shedding/ balding despite being on what is considered to be a effective treatment plan for AGA. Considering Dut (oral) . Please help.

community C’est terrible - at my wits end

community DIY treatment... Shedding completely stopped after 1.5 yrs