Ligand-Independent Actions of Vitamin D Receptor

December 2017 in “ Elsevier eBooks ”

Gilles Laverny, Daniel Metzger

vitamin D receptor VDR 1,25(OH)2D3 hair follicle homeostasis alopecia vitamin D analogues calcitriol hair follicle health hair loss

TLDR The vitamin D receptor helps maintain hair and bone health even without binding vitamin D.

The study highlighted that the vitamin D receptor (VDR) has ligand-independent actions crucial for maintaining hair follicle homeostasis, beyond its known role in regulating calcium levels and bone integrity. It was observed that mice deficient in 1,25(OH)2D3 had more severe rickets than VDR-null mice, suggesting that unliganded VDR is active. Further research in mice with 1,25(OH)2D3-binding deficient VDRs showed that unliganded VDR represses many genes and causes more severe skeletal and mineral ion defects than VDR-null mice, although only the latter exhibited alopecia. The findings suggested potential treatments using vitamin D analogues for patients with VDR mutations that impair 1,25(OH)2D3 binding.

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Research cited in this study

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research Effect of a Transcriptionally Inactive or Absent Vitamin D Receptor on Beta-Cell Function and Glucose Homeostasis in Mice

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research A Humanized Mouse Model of Hereditary 1,25-Dihydroxyvitamin D–Resistant Rickets Without Alopecia

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277 citations, July 2002 in “Molecular Endocrinology”

Removing part of the vitamin D receptor stops vitamin D from working properly.

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research Extraskeletal Actions of Vitamin D

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Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Ligand-Independent Actions of Vitamin D Receptor

Research cited in this study

research Effect of a Transcriptionally Inactive or Absent Vitamin D Receptor on Beta-Cell Function and Glucose Homeostasis in Mice

research A Humanized Mouse Model of Hereditary 1,25-Dihydroxyvitamin D–Resistant Rickets Without Alopecia

research Mutations in the Vitamin D Receptor and Hereditary Vitamin D-Resistant Rickets

research Hairless Modulates Ligand-Dependent Activation of the Vitamin D Receptor-Retinoid X Receptor Heterodimer

research Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes

research Deletion of DNA Binding Domain of the Vitamin D Receptor Abrogates Genomic and Nongenomic Functions of Vitamin D

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