Effect of a Transcriptionally Inactive or Absent Vitamin D Receptor on Beta-Cell Function and Glucose Homeostasis in Mice

February 2016 in “ Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology ”

Pieter Gillard, Heidi Wolden-Kirk, Katleen Lemaire, Annemieke Verstuyf, Lieve Verlinden, Yasutake Yamamoto, Shigeaki Kato, Leentje Van Lommel, Frans Schuit, Bart Van der Schueren, Chantal Mathieu, Lut Overbergh

vitamin D receptor VDR beta-cell function glucose homeostasis VDR knockout phosphodiesterase 10a glucose tolerance insulin secretion PDE10A

Studysummary In this study, researchers observed that the absence of the vitamin D receptor or its ligand-activated transcription in mice did not affect glucose homeostasis or gene expression in islets.

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research Ligand-Independent Actions of the Vitamin D Receptor Maintain Hair Follicle Homeostasis

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This study found that the effects of the vitamin D receptor on hair follicle cycling in mice are independent of its ability to bind a hormone, with specific domain mutations influencing hair regrowth outcomes.

research Normalization of Mineral Ion Homeostasis by Dietary Means Prevents Hyperparathyroidism, Rickets, and Osteomalacia, But Not Alopecia in Vitamin D Receptor-Ablated Mice

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The study found that normalizing mineral ion levels in vitamin D receptor-ablated mice prevented hyperparathyroidism and bone disorders but did not address hair loss, indicating the VDR's role in hair growth.