Emerging Topics in Cardiometabolic and Psychological Sequelae, Pathogenesis, and Treatment of Polycystic Ovarian Syndrome: A Review

July 2019 in “ Children (Basel) ”

Rachana Shah

Polycystic Ovarian Syndrome PCOS insulin resistance Rotterdam criteria gut microbiome genetic factors epigenetic factors diabetes medications nutritional supplements

TLDR The review concludes that more research is needed to better improve the health outcomes for people with Polycystic Ovarian Syndrome.

The 2019 review addressed the multifaceted nature of Polycystic Ovarian Syndrome (PCOS), affecting 6-10% of women of reproductive age, and its impact on various health aspects including reproductive, metabolic, dermatologic, and psychiatric health. It emphasized the unknown pathogenesis of PCOS and the focus on symptom management for treatment. The review covered the diagnostic criteria for PCOS, such as the Rotterdam criteria, and management strategies that include regulating menstrual cycles and addressing mental health issues. It also discussed the cardiometabolic risks like insulin resistance and mood disorders associated with PCOS. Advances in understanding the role of the gut microbiome, genetic and epigenetic factors in PCOS were mentioned, along with novel treatments being explored, including diabetes medications and nutritional supplements. The review concluded that despite progress, further research is essential for improving the long-term health outcomes for individuals with PCOS.

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Research cited in this study

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research Selenium and Polycystic Ovary Syndrome: Current Knowledge and Future Directions

16 citations, May 2019 in “Hormone and Metabolic Research”

Selenium might help with insulin resistance and cholesterol in PCOS, but more research is needed to confirm its benefits.

research Do Different Diagnostic Criteria Impact Polycystic Ovary Syndrome Diagnosis for Adolescents?

16 citations, December 2017 in “Journal of Pediatric and Adolescent Gynecology”

Different diagnostic criteria greatly affect PCOS diagnosis rates in teenagers.

American Association of Clinical Endocrinologists, American College of Endocrinology, and Androgen Excess and PCOS Society Disease State Clinical Review: Guide to the Best Practices in the Evaluation and Treatment of Polycystic Ovary Syndrome - Part 1

research American Association of Clinical Endocrinologists, American College of Endocrinology, and Androgen Excess and PCOS Society Disease State Clinical Review: Guide to the Best Practices in the Evaluation and Treatment of Polycystic Ovary Syndrome - Part 1

343 citations, October 2015 in “Endocrine Practice”

The guide recommends specific methods for diagnosing PCOS and various treatments for its symptoms, while considering the health impacts on adolescents.

research Putative Role for Insulin Resistance in Depression Risk in Polycystic Ovary Syndrome

46 citations, June 2015 in “Fertility and Sterility”

Insulin resistance is significantly linked to a higher risk of depression in women with PCOS.

Fetal Programming of Polycystic Ovary Syndrome by Androgen Excess: Evidence from Experimental, Clinical, and Genetic Association Studies

research Fetal Programming of Polycystic Ovary Syndrome by Androgen Excess: Evidence from Experimental, Clinical, and Genetic Association Studies

253 citations, March 2006 in “The Journal of Clinical Endocrinology and Metabolism”

Exposure to too much androgen before birth might cause polycystic ovary syndrome later in life.

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