Putative Role for Insulin Resistance in Depression Risk in Polycystic Ovary Syndrome

The document summarizes a cross-sectional study of 301 women with polycystic ovary syndrome (PCOS) that examined the link between insulin resistance and depression risk, independent of BMI. The study found that 44% of the women were at risk for depression, with those at risk having higher BMI and elevated HOMA-IR levels. After adjusting for various factors, each unit increase in HOMA-IR was associated with a 7% increase in the odds of depression risk. The study concluded that insulin resistance is significantly associated with depression risk in women with PCOS and highlighted the importance of mental health assessment in the comprehensive care of PCOS patients. The study suggests a bidirectional relationship between insulin resistance and depression and calls for further research to clarify this association and develop effective intervention strategies.