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Glossary Epigenetic Factors

external influences that modify gene expression without altering DNA

Epigenetic factors are external or environmental influences that can modify the way genes are expressed without changing the underlying DNA sequence. These factors can include diet, stress, and exposure to toxins, and they can affect how cells read genes, potentially leading to changes in physical traits or susceptibility to diseases like alopecia.

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Research

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research Understanding Pattern Hair Loss—Hair Biology Impacted by Genes, Androgens, Prostaglandins and Epigenetic Factors

3 citations , October 2021 in “Indian Journal of Plastic Surgery”

The authors concluded that pattern hair loss is a complex condition with limited treatment efficacy and two FDA-approved drugs, finasteride and minoxidil, to slow its progression.

research Facial skin aging: an integrative analysis of genetics, epigenetics, and lifestyle factors

December 2025 in “GeroScience”

This study found that both genetic and epigenetic factors significantly influence age-related facial skin aging, with lifestyle and environmental factors also playing a substantial role.

research Epigenetic regulation and factors that influence the effect of iPSCs-derived neural stem/progenitor cells (NS/PCs) in the treatment of spinal cord injury

13 citations , February 2024 in “Clinical Epigenetics”

In this study, the authors review how epigenetic regulation influences the role of iPSC-derived neural stem/progenitor cells in spinal cord injury therapy, highlighting challenges in the cells' generation, differentiation, and transplantation, and the effect of therapeutic tools on these processes.

All Roads Lead to the Nucleus: Integration of Signaling, Transcription Factor-Mediated, and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

research All Roads Go to the Nucleus: Integration of Signaling/Transcription Factor-Mediated and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

January 2018 in “Stem cell biology and regenerative medicine”

This review discusses the interplay between signaling/transcription factor-mediated and epigenetic mechanisms in skin development and regeneration, highlighting the need for further exploration of epigenome reorganization in these processes.

research The pioneer factor SOX9 competes for epigenetic factors to switch stem cell fates

6 citations , July 2023 in “Nature cell biology”

In this study, re-activating SOX9 in adult epidermal stem cells led to a fate switch towards hair follicle stem cell identity, with altered chromatin dynamics and oncogenic activation, contributing insights into developmental processes and cancer pathways.

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Community Join

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community How much hair growth potential can be lost due to lifestyle factors?

in Treatment 9 upvotes 11 months ago

Lifestyle factors like diet, stress, and nutrient deficiencies can impact hair regrowth, but their effects vary among individuals. Treatments mentioned include finasteride, dutasteride, and minoxidil.

community abusing caffeine boosts DHT levels!

in Research/Science 1 upvotes 1 year ago

Caffeine intake may increase DHT levels, but its impact on hair loss is minimal compared to genetic factors. Excessive caffeine can cause health issues, and its effects on hair loss are not directly applicable to humans based on rat studies.

community Creatine and Hair Loss: Are the studies misleading?

74 upvotes 1 month ago

Some users believe creatine may cause hair loss, citing anecdotal evidence and criticizing study flaws. Others argue there's no proven link between creatine and hair loss, suggesting any shedding might be due to other factors or genetic predisposition.

community Does dutasteride stop hair loss forever?

in Finasteride/Dutasteride 38 upvotes 1 year ago

Dutasteride and finasteride can significantly slow or halt hair loss, with some users experiencing regrowth, but results vary. Lifestyle factors and individual genetic predispositions also play a role in hair loss outcomes.

community Desensitize Follicle Sensitivity to DHT?

12 upvotes 2 weeks ago

Hair follicles cannot be desensitized to DHT like allergies; treatments focus on reducing DHT levels or blocking its effects using methods like finasteride, GT20029, or PROTACs. Topical treatments like ceterizine and BPA application are also mentioned.

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Clinics

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SMP
Diana Cárdenas ESTÉTICA AVANZADA, EPIGENÉTICA Y MICROPIGMENTACIÓNLleida, Catalunya · ES

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