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Glossary Histone Methylation

process adding methyl groups to histone proteins, affecting gene expression

Histone methylation is a biological process where methyl groups are added to histone proteins, which help package DNA in cells. This modification can either activate or repress gene expression, influencing how genes are turned on or off. For professionals, it's a key epigenetic mechanism that affects chromatin structure and function, playing a crucial role in development, differentiation, and disease.

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research Non-histone Methylation of SET7/9 and its Biological Functions

3 citations , December 2021 in “Recent patents on anti-cancer drug discovery”

This review examines the role of SET7/9 in non-histone methylation and its implications in various diseases, including cancer, but presents no new clinical results.

research Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease

667 citations , May 2008 in “Genes & Development”

This review discusses the biochemical and biological functions of histone demethylases and their potential involvement in human diseases, including cancer, but reports no new findings.

research Epidermal Stem Cells Are Defined by Global Histone Modifications that Are Altered by Myc-Induced Differentiation

98 citations , August 2007 in “PLoS ONE”

This study found that Myc activation in epidermal stem cells leads to chromatin modifications that promote stem cell exit and differentiation, which can be influenced by HDAC inhibitors like trichostatin A.

research Signalling couples hair follicle stem cell quiescence with reduced histone H3 K4/K9/K27me3 for proper tissue homeostasis

31 citations , April 2016 in “Nature communications”

This study found that in adult mouse skin, reduced levels of histone H3 K4/K9/K27me3 during hair follicle stem cell quiescence are linked to proper tissue homeostasis.

research Epigenetic control of adult stem cell function

179 citations , July 2016 in “Nature Reviews Molecular Cell Biology”

This review examines how epigenetic dysregulation affects adult stem cell function, noting that impacts range from minor to serious disruptions in tissue homeostasis and potential cancer development.

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community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 3 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community So I just continue Finasteride for the rest of my life and I get to keep my hair?

in Finasteride/Dutasteride 157 upvotes 1 year ago

Finasteride can help maintain hair and slow hair loss, but its effectiveness varies by individual. Some may switch to dutasteride or add minoxidil for better results, though side effects are a concern.

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