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GlossaryHistone Methylation

process adding methyl groups to histone proteins, affecting gene expression

Histone methylation is a biological process where methyl groups are added to histone proteins, which help package DNA in cells. This modification can either activate or repress gene expression, influencing how genes are turned on or off. For professionals, it's a key epigenetic mechanism that affects chromatin structure and function, playing a crucial role in development, differentiation, and disease.

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learn Valproic acid

an anticonvulsant repurposed for hair loss via histone inhibition

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research Non-Histone Methylation of SET7/9 and Its Biological Functions

3 citations , December 2021 in “Recent patents on anti-cancer drug discovery”

SET7/9 enzyme affects cell growth and diseases like cancer, diabetes, and obesity.

research Erasing the Methyl Mark: Histone Demethylases at the Center of Cellular Differentiation and Disease

667 citations , May 2008 in “Genes & Development”

Histone demethylases can change gene expression and may be linked to diseases like cancer.

research Epidermal Stem Cells Are Defined by Global Histone Modifications Altered by Myc-Induced Differentiation

98 citations , August 2007 in “PLoS ONE”

Myc changes chromatin in stem cells, causing them to leave their niche.

research Signaling Couples Hair Follicle Stem Cell Quiescence With Reduced Histone H3 K4/K9/K27me3 for Proper Tissue Homeostasis

31 citations , April 2016 in “Nature communications”

Certain signals are important for reducing specific chemical markers on hair follicle stem cells during rest periods, which is necessary for healthy hair growth.

research The Role of Histone Demethylases in Disease

1 citations , January 2011 in “Springer eBooks”

Histone demethylases play a key role in the development of many diseases and may be targets for treatment.

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community So I just continue Finasteride for the rest of my life and I get to keep my hair?

in Finasteride/Dutasteride 157 upvotes 4 months ago

Finasteride can help maintain hair and slow hair loss, but its effectiveness varies by individual. Some may switch to dutasteride or add minoxidil for better results, though side effects are a concern.

community Prolactin’s role in antitumor activity of the immune system – a safety concern for HMI-115?

in Research/Science 3 upvotes 2 years ago

Hair loss discussion includes treatments Minoxidil, Finasteride, and RU58841. Prolactin's role in immune system's antitumor activity raises safety concerns for HMI-115.