Epigenetics of Colorectal Cancer
September 2012
in “
Gastroenterology
”
TLDR Colorectal cancer development involves both genetic changes and epigenetic alterations like DNA methylation and microRNA changes.
The document "Epigenetics of Colorectal Cancer" from 2012 reviewed the significant role of epigenetic modifications, such as DNA methylation, histone modifications, and microRNAs (miRNAs), in the development and progression of colorectal cancer (CRC). It highlighted how these changes influence gene expression and contribute to cancer by affecting key regulatory pathways. The study underscored the potential of targeting epigenetic modifications for new therapeutic strategies and the importance of early detection through epigenetic biomarkers. Specific miRNAs and hypermethylated genes were identified as valuable for early diagnosis, prognosis, and treatment response, emphasizing the complexity and clinical relevance of epigenetic regulation in CRC.
