The Exploration of Mitochondrial-Related Features Helps to Reveal the Prognosis and Immunotherapy Methods of Colorectal Cancer

This study investigates the role of mitochondrial-related genes (MRGs) in colorectal cancer (CRC) prognosis and immunotherapy, using data from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). Researchers developed a predictive model based on MRG risk scores, identifying five key genes (TRAP1, HIGD1A, PPARGC1A, EFHD1, and P4HA1) that effectively stratify patients into high- and low-risk groups. The model demonstrates superior predictive performance for overall survival (OS) and progression-free survival (PFS) compared to other models. High-risk groups show increased immune cell infiltration and immune checkpoint gene expression, suggesting implications for immunotherapy. The study highlights the potential of MRGs as biomarkers for CRC prognosis and therapy optimization, emphasizing their value in personalized cancer treatment strategies.