The Exploration of Mitochondrial-Related Features Helps to Reveal the Prognosis and Immunotherapy Methods of Colorectal Cancer

The study explores the relationship between mitochondrial-related features and the tumor microenvironment (TME) in colorectal cancer (CRC), using non-negative matrix factorization (NMF) clustering to analyze patient data. It identifies two distinct groups of CRC patients with significant differences in survival outcomes and TME. A prognostic model based on mitochondrial-related gene (MRG) risk scores was developed and validated, showing strong predictive power for survival and immunotherapy success. The study highlights the importance of MRG features in understanding immune cell infiltration and responsiveness to immunotherapy, providing valuable insights for creating individualized treatment plans for CRC patients.