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GlossaryHistone H3

protein that helps package DNA into chromatin

Histone H3 is a protein that helps package DNA into a compact, organized structure called chromatin within the cell nucleus. It plays a crucial role in regulating gene expression by allowing or restricting access to specific DNA regions, which can influence various biological processes, including hair growth and the development of conditions like alopecia.

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learn Valproic acid

an anticonvulsant repurposed for hair loss via histone inhibition

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research Signaling Couples Hair Follicle Stem Cell Quiescence With Reduced Histone H3 K4/K9/K27me3 for Proper Tissue Homeostasis

31 citations , April 2016 in “Nature communications”

Certain signals are important for reducing specific chemical markers on hair follicle stem cells during rest periods, which is necessary for healthy hair growth.

research Histone H3 K4/9/27 Trimethylation Levels Affect Wound Healing and Stem Cell Dynamics in Adult Skin

26 citations , December 2019 in “Stem Cell Reports”

Proper tissue repair in adult skin requires specific histone hypomethylation.

research The Role of Histone Demethylases in Disease

1 citations , January 2011 in “Springer eBooks”

Histone demethylases play a key role in the development of many diseases and may be targets for treatment.

research Genome-Wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage

191 citations , September 2011 in “Cell stem cell”

Hair follicle stem cells use specific chromatin changes to control their growth and differentiation.

research Abnormal Epigenetic Modifications in Peripheral Blood Mononuclear Cells from Patients with Alopecia Areata

48 citations , September 2011 in “British Journal of Dermatology”

Epigenetic changes in blood cells may contribute to alopecia areata.

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community Prolactin’s role in antitumor activity of the immune system – a safety concern for HMI-115?

in Research/Science 3 upvotes 2 years ago

Hair loss discussion includes treatments Minoxidil, Finasteride, and RU58841. Prolactin's role in immune system's antitumor activity raises safety concerns for HMI-115.

community So I just continue Finasteride for the rest of my life and I get to keep my hair?

in Finasteride/Dutasteride 157 upvotes 6 days ago

Finasteride can help maintain hair and slow hair loss, but its effectiveness varies by individual. Some may switch to dutasteride or add minoxidil for better results, though side effects are a concern.