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    Glossary Histone H3

    protein that helps package DNA into chromatin

    Histone H3 is a protein that helps package DNA into a compact, organized structure called chromatin within the cell nucleus. It plays a crucial role in regulating gene expression by allowing or restricting access to specific DNA regions, which can influence various biological processes, including hair growth and the development of conditions like alopecia.

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    1. Signalling couples hair follicle stem cell quiescence with reduced histone H3 K4/K9/K27me3 for proper tissue homeostasis Nature communications · 2016 · 31 citations
    2. Histone H3 K4/9/27 Trimethylation Levels Affect Wound Healing and Stem Cell Dynamics in Adult Skin Stem Cell Reports · 2019 · 26 citations
    3. EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair Genes & Development · 2011 · 354 citations
    4. The Role of Histone Demethylases in Disease Springer eBooks · 2011 · 1 citations
    5. Photo-downregulation of SIRT4 mitigates aging in mice by enhancing H3K9ac via fatty acid metabolism eLife · 2026
    6. Photo-downregulation of SIRT4 mitigates aging in mice by enhancing H3K9ac via fatty acid metabolism eLife · 2026
    7. H3K9me3 controls epidermis morphogenesis by regulating RNA Pol II dynamics at developmental promoters and enhancers Nature Communications · 2026
    8. H3K4me3 regulates the transcription of RSPO3 in dermal papilla cells to influence hair follicle morphogenesis and development Epigenetics & Chromatin · 2025 · 1 citations
    9. GCN5-mediated H3K27cr regulates hair follicle stem cell migration and hair follicle development through KRT80 activation Communications Biology · 2026
    10. Epidermal Stem Cells Are Defined by Global Histone Modifications that Are Altered by Myc-Induced Differentiation PLoS ONE · 2007 · 98 citations
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