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Glossary Enhancer of Zeste Homolog 2

gene encoding an enzyme that represses gene expression via methylation

Enhancer of Zeste Homolog 2 (EZH2) is a gene that encodes an enzyme involved in modifying chromatin, which is the complex of DNA and proteins in the cell nucleus. This enzyme adds methyl groups to histone proteins, leading to the repression of gene expression. EZH2 is important in regulating cell division and differentiation, and its dysregulation is often associated with various cancers.

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Research

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research 102 EZH2 is required for human hair follicle growth and epidermal differentiation

August 2016 in “Journal of Investigative Dermatology”

In this ex vivo study, inhibiting Ezh2 with a small molecule slowed human hair growth by decreasing proliferation and increasing apoptosis in the outer root sheath.

research EZH2-mediated inhibition of microRNA-22 promotes differentiation of hair follicle stem cells by elevating STK40 expression

12 citations , July 2020 in “Aging”

This study found that the enhancer of zeste homolog 2 (EZH2) may promote hair growth by increasing STK40 expression and facilitating hair follicle stem cell proliferation and differentiation.

Expression of EZH2 in the Skin of Developing Human Fetuses and Adults: A Comparative Study

research Gelişmekte olan insan fetüslerinin ve yetişkinlerin derisinde EZH2 ekspresyonu: karşılaştırmalı bir çalışma

September 2023 in “Çukurova medical journal (Online)/Çukurova medical journal”

This study observed that EZH2 expression scores in the epidermis, dermis, and hair follicles decrease with gestational age in human fetuses, and these scores were significantly higher in adults, indicating that lower EZH2 levels may be required for full skin differentiation and maturation before birth.

Botulinum Neurotoxin Type A Combined With Platelet-Rich Plasma Promotes Hair Follicle Growth And Regeneration Via STMN1 Modulation And Wnt/β-Catenin Pathway Activation

research Botulinum Neurotoxin Type A Combined with Platelet-Rich Plasma Promotes Hair Follicle Growth and Regeneration via STMN1 Modulation and Wnt/β-Catenin Pathway Activation

November 2025 in “Journal of Microbiology and Biotechnology”

In this study, combining Botulinum toxin type A with Platelet-rich plasma was found to enhance hair follicle growth and reconstruction, potentially through inflammation reduction and activation of the Wnt/β-catenin pathway via STMN1 protein modulation.

research Stem Cells on Alert: Priming Quiescent Stem Cells after Remote Injury

13 citations , July 2014 in “Cell stem cell”

This study identified a novel phase of stem cell quiescence, GAlert, in mice, regulated by mTORC1, that primes stem cells for injury response.

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Hair TransplantHair Loss TreatmentsSMP
International Society of Hair Restoration SurgeryElgin, IL · US

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