Verteporfin
Verteporfin is a photosensitizing agent originally developed for photodynamic therapy (PDT) in the treatment of macular degeneration and certain types of cancer. Since its approval for clinical use, verteporfin's applications have expanded beyond ophthalmology and oncology, exploring its potential in other medical fields, including dermatology and alopecia treatment.
Verteporfin has more recently garnered attention in the field of dermatology and hair loss treatment for a unique mechanism of action, blocking the Engrailed-1 fibroblast pathway, which is critical in the formation of scar tissue following injury. Research has shown that when applied to surgical wounds in mice, verteporfin can prevent the typical scar formation associated with wound healing, promoting the regeneration of hair follicles, sebaceous glands, and the extracellular matrix instead. This finding has significant implications for the hair transplant industry, suggesting that verteporfin could revolutionize hair restoration techniques by producing new follicles in the wounded, extracted area.
Within the community, discussions around verteporfin are marked by cautious but high optimism and a focus on its potential to transform hair transplant surgery. Community members are exploring the possibilities of combining verteporfin with other treatments like microneedling to enhance hair regrowth and minimize scarring. The sentiment is generally positive, with many interested in the ongoing research and potential applications of verteporfin in hair loss treatment strategies.
Research
17 / 17 results
research Inhibition of the Hippo Pathway by Verteporfin Reduces the Proliferation and Stemness of Rat Hair Follicle Neural Crest Stem Cells Under Hypoxia
research Multimodal Molecular Analysis Reveals Divergent Trajectories of Wound Regeneration Versus Fibrosis
research Current Therapeutic Approaches to Chronic Central Serous Chorioretinopathy
research Finasteride Is Effective for the Treatment of Central Serous Chorioretinopathy
research Applications and Risks of Nanomaterials Used in Regenerative Medicine, Delivery Systems, Theranostics, and Therapy
research Interventions for Central Serous Chorioretinopathy: A Network Meta-Analysis
research Trends in Nanotechnology for Practical Applications
research Dermatological Medications and Local Therapeutics During Pregnancy
research Mechanical Forces Across Compartments Coordinate Cell Shape and Fate Transitions to Generate Tissue Architecture
research Interventions for Central Serous Chorioretinopathy: A Network Meta-Analysis
research Recent Advances in the Structural Design of Photosensitive Agent Formulations Using Soft Colloidal Nanocarriers
research Non-Viral Delivery of the CRISPR/Cas System: DNA Versus RNA Versus RNP
research Stimuli-Responsive Nanoformulations for CRISPR-Cas9 Genome Editing
research Targeting the Hippo/YAP/TAZ Signalling Pathway: Novel Opportunities for Therapeutic Interventions into Skin Cancers
research Hair Follicle Morphogenesis During Embryogenesis, Neogenesis, and Organogenesis
research A Skin Organoid-Based Infection Platform Identifies an Inhibitor Specific for Hand, Foot, and Mouth Disease
