A Skin Organoid-Based Infection Platform Identifies an Inhibitor Specific for Hand, Foot, and Mouth Disease

March 2025 in “ Nature Communications ”

Jun Li, Jie Ma, Ruiyuan Cao, Qiyu Zhang, Mansheng Li, Wenwen Wang, Yujie Wang, Wei Li, Yunping Zhu, Ling Leng

human induced pluripotent stem cell-derived skin organoids hiPSC-SOs Enterovirus 71 EV-A71 fibroblasts epidermal cells autophagy epidermal progenitor cells NSC167409 hair follicle stem cells skin organoid models

Studysummary This study used human stem cell-derived skin organoids to model EV-A71 infection, revealing that various skin cell types are susceptible to the virus and identifying a potential drug target and replication inhibitor, suggesting its utility for studying skin infectious diseases and drug screening.

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