Generation of Human-Induced Pluripotent Stem Cell-Derived Adherent 3-Dimensional Skin Hair-Follicle Organoids

    September 2022 in “ Organoid ”
    Nhu Thi Quynh, Ulziituya Batjargal, Hyeon Song … Byoung-San Moon
    Studysummary In this study, the researchers developed a new protocol using human-induced pluripotent stem cells to efficiently create skin hair follicle organoids, which may aid in optimizing hair follicle growth and exploring treatments for alopecia.
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    Research cited in this study 23

    1. Recent Progress in Understanding the Effect of Sympathetic Nerves on Hair Follicle Growth Frontiers in Cell and Developmental Biology · 2021
    2. Functional Hair Follicle Regeneration: An Updated Review Signal Transduction and Targeted Therapy · 2021
    3. Skin Organoids: A New Human Model for Developmental and Translational Research Experimental Dermatology · 2021
    4. Hair-Bearing Human Skin Generated Entirely From Pluripotent Stem Cells Nature · 2020
    5. Tissue Engineering of Human Hair Follicles Using a Biomimetic Developmental Approach Nature Communications · 2018
    6. Establishment of an In Vitro Organoid Model of Dermal Papilla of Human Hair Follicle Journal of Cellular Physiology · 2018
    7. Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids Cell Reports · 2018
    8. Assembling Composite Dermal Papilla Spheres with Adipose-Derived Stem Cells to Enhance Hair Follicle Induction Scientific Reports · 2016
    9. Bioengineering a 3D Integumentary Organ System from iPS Cells Using an In Vivo Transplantation Model Science Advances · 2016
    10. Advances in Skin Grafting and Treatment of Cutaneous Wounds Science · 2014
    11. Generation of Folliculogenic Human Epithelial Stem Cells from Induced Pluripotent Stem Cells Nature communications · 2014
    12. Stem Cell Dynamics in the Hair Follicle Niche Seminars in Cell & Developmental Biology · 2013
    13. Pattern Hair Loss in Men: Diagnosis, Genetic Link, Clinical Features, and Treatments Dermatologic Clinics · 2012
    14. Hair Organ Regeneration Via Bioengineered Hair Follicular Unit Transplantation Scientific Reports · 2012
    15. Fully Functional Hair Follicle Regeneration Through the Rearrangement of Stem Cells and Their Niches Nature Communications · 2012
    16. De Novo Formation and Ultra-Structural Characterization of a Fiber-Producing Human Hair Follicle Equivalent In Vitro Journal of biotechnology · 2011
    17. Microenvironmental Reprogramming of Thymic Epithelial Cells to Skin Multipotent Stem Cells Nature · 2010
    18. Hair Restoration in the Ethnic Patient and Review of Hair Transplant Fundamentals Facial Plastic Surgery Clinics of North America · 2010
    19. Sox2-Positive Dermal Papilla Cells Specify Hair Follicle Type in Mammalian Epidermis Development · 2009
    20. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    21. Isolation and Short-Term Culture of Primary Keratinocytes, Hair Follicle Populations, and Dermal Cells from Newborn Mice and Keratinocytes from Adult Mice for In Vitro Analysis and Grafting to Immunodeficient Mice Nature Protocols · 2008
    22. Building Epithelial Tissues From Skin Stem Cells Cold Spring Harbor Symposia on Quantitative Biology · 2008
    23. The Hair Cycle Journal of Cell Science · 2006