Generation of Folliculogenic Human Epithelial Stem Cells from Induced Pluripotent Stem Cells

January 2014 in “ Nature communications ”

Ruifeng Yang, Ying Zheng, Michelle Burrows, Shujing Liu, Zhi Wei, Arben Nace, Wei Guo, Suresh Kumar, George Cotsarelis, Xiaowei Xu

TLDR Scientists created stem cells that can grow hair and skin.

Researchers developed a method to differentiate human induced pluripotent stem cells (hiPSCs) into CD200+/ITGA6+ epithelial stem cells (EpSCs) that can regenerate the epithelial components of hair follicles and interfollicular epidermis. These hiPSC-derived cells exhibited a gene expression profile similar to EpSCs isolated directly from human hair follicles and were capable of generating all hair follicle lineages, including the hair shaft and root sheaths, in skin reconstitution assays. The regenerated follicles contained a KRT15+ stem cell population and produced hair shafts with hair-specific keratins. This approach suggested potential for generating large numbers of human EpSCs for tissue engineering and treatments for hair loss, wound healing, and degenerative skin disorders.

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research Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells

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research Effects of EGF on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles

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EGF makes hair follicles grow longer but stops hair production.

Generation of Folliculogenic Human Epithelial Stem Cells from Induced Pluripotent Stem Cells

Cited in this study

research Human Induced Pluripotent Stem Cell-Derived Ectodermal Precursor Cells Contribute to Hair Follicle Morphogenesis In Vivo

research Differentiation of Mouse Induced Pluripotent Stem Cells into a Multipotent Keratinocyte Lineage

research Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells

research Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells

research Multi-Potentiality of a New Immortalized Epithelial Stem Cell Line Derived from Human Hair Follicles

research Hair Follicle Regeneration Using Grafted Rodent and Human Cells

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

research Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells

research Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells

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