Generation of Folliculogenic Human Epithelial Stem Cells from Induced Pluripotent Stem Cells

    January 2014 in “ Nature communications ”
    Ruifeng Yang, Ying Zheng, Michelle Burrows … Xiaowei Xu
    Studysummary In this study, researchers developed a method to differentiate human iPSCs into cells that can generate all lineages of hair follicles, potentially aiding treatments for hair loss and skin disorders.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on nature.com →
    Discuss this study in the Community →

    Research cited in this study 11

    1. Human Induced Pluripotent Stem Cell-Derived Ectodermal Precursor Cells Contribute to Hair Follicle Morphogenesis In Vivo ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2013
    2. The Circadian Molecular Clock Creates Epidermal Stem Cell Heterogeneity Nature · 2011
    3. Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells Journal of Clinical Investigation · 2011
    4. Differentiation of Mouse Induced Pluripotent Stem Cells into a Multipotent Keratinocyte Lineage ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2010
    5. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    6. Multi-Potentiality of a New Immortalized Epithelial Stem Cell Line Derived from Human Hair Follicles In vitro cellular & developmental biology. Animal · 2008
    7. Isolation and Short-Term Culture of Primary Keratinocytes, Hair Follicle Populations, and Dermal Cells from Newborn Mice and Keratinocytes from Adult Mice for In Vitro Analysis and Grafting to Immunodeficient Mice Nature Protocols · 2008
    8. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    9. Hair Follicle Regeneration Using Grafted Rodent and Human Cells Journal of Investigative Dermatology · 2007
    10. Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2005
    11. Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells Journal of Investigative Dermatology · 2005

    Related research 3

    1. Expression of E6 and E7 Papillomavirus Oncogenes in the Outer Root Sheath of Hair Follicles Extends the Growth Phase and Bypasses Resting at Telogen PubMed · 2000
    2. Effects of Epidermal Growth Factor on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1994
    3. Outer Root Sheath Keratinization in Anagen and Catagen of the Mammalian Hair Follicle: A Seventh Distinct Type of Keratinization in the Hair Follicle - Trichilemmal Keratinization PubMed · 1981