Generation of Folliculogenic Human Epithelial Stem Cells from Induced Pluripotent Stem Cells

    January 2014 in “ Nature communications ”
    Ruifeng Yang, Ying Zheng, Michelle Burrows, Shujing Liu, Zhi Wei, Arben Nace, Wei Guo, Suresh Kumar, George Cotsarelis, Xiaowei Xu
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    TLDR Scientists created stem cells that can grow hair and skin.
    Researchers developed a method to differentiate human induced pluripotent stem cells (hiPSCs) into CD200+/ITGA6+ epithelial stem cells (EpSCs) that can regenerate the epithelial components of hair follicles and interfollicular epidermis. These hiPSC-derived cells exhibited a gene expression profile similar to EpSCs isolated directly from human hair follicles and were capable of generating all hair follicle lineages, including the hair shaft and root sheaths, in skin reconstitution assays. The regenerated follicles contained a KRT15+ stem cell population and produced hair shafts with hair-specific keratins. This approach suggested potential for generating large numbers of human EpSCs for tissue engineering and treatments for hair loss, wound healing, and degenerative skin disorders.
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