De Novo Formation and Ultra-Structural Characterization of a Fiber-Producing Human Hair Follicle Equivalent In Vitro

March 2011 in “ Journal of biotechnology ”

G Lindner, Reyk Horland, Ilka Wagner, Beren Ataç, Roland Lauster

TLDR Scientists recreated human hair follicles in the lab that can grow hair.

Researchers successfully recreated human hair follicles in vitro that were capable of producing hair by carefully replicating the growth conditions of hair follicle formation. These microfollicles contained all relevant cell types and structurally resembled excised hair follicle specimens from human skin. This achievement provided a new perspective on hair follicle development and represented a significant step towards improved hair regeneration and understanding the effects of drugs, including chemotherapy, on hair follicles.

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research The Mesenchymal Component of Hair Follicle Neogenesis: Background, Methods, and Molecular Characterization

131 citations , February 2010 in “Experimental Dermatology”

The document concludes that specific cells are essential for hair growth and more research is needed to understand how to maintain their hair-inducing properties.

research Review of Hair Follicle Dermal Cells

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Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.

research The Hair Follicle as a Dynamic Mini-Organ

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EVAL membranes help create cell structures that can regrow hair follicles.

research Scratching the Surface of Skin Development

788 citations , February 2007 in “Nature”

The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.

research Simple and Rapid Method to Isolate and Culture Follicular Papillae from Human Scalp Hair Follicles

78 citations , August 2002 in “Experimental Dermatology”

Researchers developed a quick and easy way to get and grow cells from the base of human hair follicles.

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4 / 4 results

research Pathobiology of Chemotherapy-Induced Hair Loss

218 citations , February 2013 in “The Lancet Oncology”

Chemotherapy causes hair loss by damaging hair follicles and stem cells, with more research needed for prevention and treatment.

research Human Hair Growth Ex Vivo Is Correlated With In Vivo Hair Growth: Selective Categorization of Hair Follicles for More Reliable Hair Follicle Organ Culture

27 citations , November 2005 in “Archives of Dermatological Research”

Choosing hair follicles at the same growth stage leads to more consistent hair growth experiments.

research Reorganization of Hair Follicles in Human Skin Organ Culture Induced by Cultured Human Follicle-Derived Cells

56 citations , July 2005 in “Experimental Dermatology”

Injected human hair follicle cells can create new, small hair follicles in skin cultures.

research Towards a Molecular Understanding of Hair Loss and Its Treatment

236 citations , July 2001 in “Trends in Molecular Medicine”

Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.