TLDR New molecules involved in skin and hair growth were identified, improving understanding and future treatments.
The document reviewed classical and molecular histological studies on skin appendage morphogenesis, focusing on the cellular organization and molecular bases of skin appendage development. It highlighted the identification of new molecules expressed during the formation of skin appendages, such as growth factors, signaling molecules, and adhesion molecules, using feather and hair as models. The review aimed to provide groundwork for molecular mapping of skin appendages, enhancing understanding of developmental processes and potentially influencing future treatment modalities for healing and regeneration.
67 citations,
February 1994 in “Developmental dynamics” Specific proteins and molecules play key roles in the development of human hair follicles.
578 citations,
April 1993 in “Cell” TGFα gene mutation in mice causes abnormal skin, wavy hair, curly whiskers, and sometimes eye inflammation.
745 citations,
February 1992 in “Trends in genetics” Hair follicles create different cell layers and proteins, controlled by various molecules.
45 citations,
December 1991 in “Annals of the New York Academy of Sciences” ECM molecules are crucial for hair growth and development.
356 citations,
December 1986 in “The journal of cell biology/The Journal of cell biology” Hair and nail cells share similar proteins, indicating a common differentiation pathway.
Researchers found a genetic link for hereditary hair loss but need more analysis to identify the exact gene.
234 citations,
April 2000 in “Gene” Msx and Dlx genes are crucial for development, controlling cell behaviors like growth and differentiation through their roles as gene regulators.
89 citations,
September 2010 in “Annual Review of Genomics and Human Genetics” The document concludes that understanding the genes and pathways involved in hair growth is crucial for developing treatments for hair diseases.
85 citations,
October 2006 in “Current opinion in cell biology” Feather growth and regeneration involve complex patterns, stem cells, and evolutionary insights.
1 citations,
November 2023 in “iScience” A protein called desmoglein 3 is important for keeping hair follicle stem cells inactive and helps in their regeneration.
