Bioengineering a 3D Integumentary Organ System from iPS Cells Using an In Vivo Transplantation Model

    April 2016 in “ Science Advances ”
    Ryo Takagi, Junko Ishimaru, Ayaka Sugawara … Takashi Tsuji
    Studysummary Researchers created a fully functional, bioengineered skin system with hair from stem cells that successfully integrated when transplanted into mice.
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    Research cited in this study 10

    1. Advances in Skin Grafting and Treatment of Cutaneous Wounds Science · 2014
    2. Functional Lacrimal Gland Regeneration by Transplantation of a Bioengineered Organ Germ Nature Communications · 2013
    3. Functional Salivary Gland Regeneration by Transplantation of a Bioengineered Organ Germ Nature Communications · 2013
    4. Tuning Wnt Signals for More or Fewer Hairs Journal of Investigative Dermatology · 2013
    5. Wnt Signaling in Skin Development, Homeostasis, and Disease Cold Spring Harbor Perspectives in Biology · 2012
    6. Hair Organ Regeneration Via Bioengineered Hair Follicular Unit Transplantation Scientific Reports · 2012
    7. Fully Functional Hair Follicle Regeneration Through the Rearrangement of Stem Cells and Their Niches Nature Communications · 2012
    8. Sox2-Positive Dermal Papilla Cells Specify Hair Follicle Type in Mammalian Epidermis Development · 2009
    9. Integument Pattern Formation Involves Genetic and Epigenetic Controls: Feather Arrays Simulated by Digital Hormone Models ˜The œInternational journal of developmental biology · 2004
    10. Hair Follicle Dermal Cells Differentiate Into Adipogenic and Osteogenic Lineages Experimental Dermatology · 2003