Regeneration of a Bioengineered 3D Integumentary Organ System from iPS Cells

    April 2019 in “ Nature protocols ”
    Koh-éi Toyoshima, Miho Ogawa, Takashi Tsuji
    TLDR Scientists created a functional 3D skin system from stem cells that can be transplanted into wounds.
    The document described a method to generate a 3D integumentary organ system (3D-IOS) from murine induced pluripotent stem (iPS) cells. The process involved growing iPS cells for 7 days to form embryoid bodies (EBs), stimulating these EBs with Wnt10b, and then transplanting them in vivo using a clustering-dependent embryoid body (CDB) transplantation method. After 30 days, the EBs differentiated into a 3D-IOS containing mature hair follicles and sebaceous glands, which could be transplanted into wounds in other mice. The transplanted 3D-IOS demonstrated full physiological function 14 days post-transplantation, showcasing the potential for creating functional organ systems from pluripotent stem cells.
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