Engineering the Niche for Hair Regeneration: A Critical Review

    Mohammad Ali Nilforoushzadeh, Mehrak Zare, Payam Zarrintaj, Effat Alizadeh, Ehsan Taghiabadi, Maryam Heidari-Kharaji, Mohammad Amir Amirkhani, Mohammad Reza Saeb, Masoud Mozafari
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    TLDR Further research is needed to improve hair regeneration using stem cells and nanomaterials.
    The document from 2019 provides a comprehensive review of the advancements in hair follicle regeneration, with a particular focus on the role of nanotechnology and induced pluripotent stem cells (iPS cells). It discusses the potential of iPS cells derived from hair follicles for cell-based therapies and the importance of engineering the stem cell niche using nanomaterials to mimic the natural hair follicle environment. The review also addresses the challenges of maintaining hair follicle cell functionality in vitro and the use of biomaterials to support cell survival and differentiation. It highlights the significance of dermal papilla cells in hair growth and the influence of material surface properties on cell behavior. The document concludes that while progress has been made, further research is needed to develop reproducible techniques for differentiating iPS cells into hair follicle components and to create nanostructured biomaterials for effective clinical hair regeneration.
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