Engineering the Niche for Hair Regeneration: A Critical Review

    Mohammad Ali Nilforoushzadeh, Mehrak Zare, Payam Zarrintaj … Masoud Mozafari
    Studysummary This review discusses recent advances in hair regeneration therapies, highlighting the potential of nanotechnology and pluripotent stem cells, and reports no new results, emphasizing the need for further research.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on doi.org →
    Discuss this study in the Community →

    Research cited in this study 50

    1. Impact of Substrate Stiffness on Dermal Papilla Aggregates in Microgels Biomaterials Science · 2018
    2. Spontaneous Hair Follicle Germ Formation In Vitro, Enabling The Large-Scale Production Of HFGs For Regenerative Medicine Biomaterials · 2017
    3. Tissue Engineering: Strategies, Tissues, And Biomaterials Biotechnology and Genetic Engineering Reviews · 2017
    4. Dermal Blimp1 Acts Downstream of Epidermal TGFβ and Wnt/β-Catenin to Regulate Hair Follicle Formation and Growth Journal of Investigative Dermatology · 2017
    5. Microfluidic Technology for the Generation of Cell Spheroids and Their Applications Micromachines · 2017
    6. Induction of Hair Follicle Dermal Papilla Cell Properties in Human Induced Pluripotent Stem Cell-Derived Multipotent LNGFR(+)THY-1(+) Mesenchymal Cells Scientific Reports · 2017
    7. Induction of Skin-Derived Precursor Cells from Human Induced Pluripotent Stem Cells PLOS ONE · 2016
    8. Dendritic Polyglycerol and N-Isopropylacrylamide Based Thermoresponsive Nanogels as Smart Carriers for Controlled Delivery of Drugs Through the Hair Follicle Nanoscale · 2016
    9. Induced Pluripotent Stem Cells From Human Hair Follicle Keratinocytes As A Potential Source For In Vitro Hair Follicle Cloning PeerJ · 2016
    10. Formulation and In Vitro Evaluation of Polymeric Enteric Nanoparticles as Dermal Carriers with pH-Dependent Targeting Potential European journal of pharmaceutical sciences · 2016
    11. Self-Assembling Peptide Hydrogel Scaffolds Support Stem Cell-Based Hair Follicle Regeneration Nanomedicine: Nanotechnology, Biology and Medicine · 2016
    12. Hair Follicle Regeneration by Transplantation of a Bioengineered Hair Follicle Germ Methods in molecular biology · 2016
    13. Cytokine Loaded Layer-By-Layer Ultrathin Matrices to Deliver Single Dermal Papilla Cells for Spot-By-Spot Hair Follicle Regeneration Journal of Materials Chemistry B · 2015
    14. Biology of the Hair Follicle and Mechanisms of Nonscarring and Scarring Alopecia Seminars in cutaneous medicine and surgery · 2015
    15. Drug Discovery for Alopecia: Gone Today, Hair Tomorrow Expert Opinion on Drug Discovery · 2015
    16. Self-Assembled Polymeric Nanocarriers for the Targeted Delivery of Retinoic Acid to the Hair Follicle Nanoscale · 2015
    17. Controllable Production of Transplantable Adult Human High-Passage Dermal Papilla Spheroids Using 3D Matrigel Culture Tissue engineering. Part A · 2014
    18. Generation of iPS Cells from Human Hair Follicle Dermal Papilla Cells Acta naturae · 2014
    19. Generation of Folliculogenic Human Epithelial Stem Cells from Induced Pluripotent Stem Cells Nature communications · 2014
    20. Efficacy and Safety of a Low-Level Laser Device in the Treatment of Male and Female Pattern Hair Loss: A Multicenter, Randomized, Sham Device-Controlled, Double-Blind Study American Journal of Clinical Dermatology · 2014
    21. Stem Cell Dynamics in the Hair Follicle Niche Seminars in Cell & Developmental Biology · 2013
    22. Squarticles as a Lipid Nanocarrier for Delivering Diphencyprone and Minoxidil to Hair Follicles and Human Dermal Papilla Cells Aaps Journal · 2013
    23. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    24. Low-Level Laser Therapy for Treatment of Hair Loss Lasers in Surgery and Medicine · 2013
    25. Dissociated Human Dermal Papilla Cells Induce Hair Follicle Neogenesis in Grafted Dermal-Epidermal Composites Journal of Investigative Dermatology · 2013
    26. Follicular Dermal Papilla Structures by Organization of Epithelial and Mesenchymal Cells in Interfacial Polyelectrolyte Complex Fibers Biomaterials · 2013
    27. Strategies to Enhance Epithelial-Mesenchymal Interactions for Human Hair Follicle Bioengineering Journal of Dermatological Science · 2013
    28. Human Induced Pluripotent Stem Cell-Derived Ectodermal Precursor Cells Contribute to Hair Follicle Morphogenesis In Vivo ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2013
    29. Therapeutic Strategy for Hair Regeneration: Hair Cycle Activation, Niche Environment Modulation, Wound-Induced Follicle Neogenesis, and Stem Cell Engineering Expert Opinion on Biological Therapy · 2013
    30. Androgenetic Alopecia: An Update Indian Journal of Dermatology, Venereology and Leprology · 2013
    31. Induced Pluripotent Stem Cells From Human Hair Follicle Mesenchymal Stem Cells Stem Cell Reviews and Reports · 2012
    32. Scalable Production of Controllable Dermal Papilla Spheroids on PVA Surfaces and the Effects of Spheroid Size on Hair Follicle Regeneration Biomaterials · 2012
    33. Hairy Tale of Signaling in Hair Follicle Development and Cycling Seminars in cell & developmental biology · 2012
    34. Fully Functional Hair Follicle Regeneration Through the Rearrangement of Stem Cells and Their Niches Nature Communications · 2012
    35. Reprogramming of Human Hair Follicle Dermal Papilla Cells into Induced Pluripotent Stem Cells Journal of Investigative Dermatology · 2012
    36. Sphere Formation Increases the Ability of Cultured Human Dermal Papilla Cells to Induce Hair Follicles from Mouse Epidermal Cells in a Reconstitution Assay Journal of Investigative Dermatology · 2011
    37. The Advantages of Hair Follicle Pluripotent Stem Cells Over Embryonic Stem Cells and Induced Pluripotent Stem Cells for Regenerative Medicine Journal of Dermatological Science · 2010
    38. Large-Scale Cultivation of Transplantable Dermal Papilla Cellular Aggregates Using Microfabricated PDMS Arrays Acta Biomaterialia · 2010
    39. Review of Hair Follicle Dermal Cells Journal of Dermatological Science · 2009
    40. Hair Follicle Neogenesis Induced by Cultured Human Scalp Dermal Papilla Cells Regenerative Medicine · 2009
    41. The Enhancement of Dermal Papilla Cell Aggregation by Extracellular Matrix Proteins Through Effects on Cell–Substratum Adhesivity and Cell Motility Biomaterials · 2009
    42. Human Hair Follicle Pluripotent Stem Cells Promote Regeneration of Peripheral Nerve Injury: An Advantageous Alternative to ES and iPS Cells Journal of Cellular Biochemistry · 2009
    43. A Human Folliculoid Microsphere Assay for Exploring Epithelial-Mesenchymal Interactions in the Human Hair Follicle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2008
    44. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    45. Medical Treatments for Male and Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2008
    46. Hair Morphogenesis In Vitro: Formation of Hair Structures Suitable for Implantation Regenerative Medicine · 2008
    47. Self-Assembly of Dermal Papilla Cells into Inductive Spheroidal Microtissues on Poly(Ethylene-Co-Vinyl Alcohol) Membranes for Hair Follicle Regeneration Biomaterials · 2008
    48. Defining Hair Follicles in the Age of Stem Cell Bioengineering Journal of Investigative Dermatology · 2007
    49. Hair Follicle Regeneration Using Grafted Rodent and Human Cells Journal of Investigative Dermatology · 2007
    50. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002

    Related research 1

    1. Induced Pluripotent Stem Cell Line MUSIi006-A Derived from Hair Follicle Keratinocytes as a Non-Invasive Somatic Cell Source Stem cell research · 2018