Hair Follicle Regeneration by Transplantation of a Bioengineered Hair Follicle Germ

January 2016 in “ Methods in molecular biology ”

Katsunari Tezuka, Koh-ei Toyoshima, Takashi Tsuji

TLDR Scientists have developed a new method using stem cells to grow and transplant hair follicles, which could be useful for hair regeneration treatments.

The document from 2015 describes a novel bioengineering technique called the Organ Germ Method, which uses three-dimensional stem cell culture to regenerate various organs and reproduce embryonic organogenesis. The method was applied to hair follicle germ reconstitution using adult follicle-derived epithelial stem cells and dermal papilla cells. The bioengineered hair follicle germ was then transplanted intracutaneously. This protocol was suggested to be useful for clinical studies of hair regeneration, as well as for studies of stem cell biology and organogenesis.

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Research cited in this study

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research Functional Salivary Gland Regeneration by Transplantation of a Bioengineered Organ Germ

165 citations , October 2013 in “Nature Communications”

Scientists made working salivary glands in mice using bioengineered cells, which could help treat dry mouth.

research Hair Organ Regeneration Via Bioengineered Hair Follicular Unit Transplantation

66 citations , May 2012 in “Scientific Reports”

Scientists successfully created and transplanted bioengineered hair follicles that function like natural ones, suggesting a new treatment for hair loss.

research Fully Functional Hair Follicle Regeneration Through the Rearrangement of Stem Cells and Their Niches

179 citations , April 2012 in “Nature Communications”

Regenerated fully functional hair follicles using stem cells, with potential for hair regrowth therapy.

research The Basement Membrane Of Hair Follicle Stem Cells Is A Muscle Cell Niche

294 citations , February 2011 in “Cell”

Nephronectin helps attach muscle cells to hair follicles.

research The Hair Follicle as a Dynamic Mini-Organ

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Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

research Isolation and Short-Term Culture of Primary Keratinocytes, Hair Follicle Populations, and Dermal Cells from Newborn Mice and Keratinocytes from Adult Mice for In Vitro Analysis and Grafting to Immunodeficient Mice

427 citations , April 2008 in “Nature Protocols”

research Defining Hair Follicles in the Age of Stem Cell Bioengineering

49 citations , September 2007 in “Journal of Investigative Dermatology”

The study found that bioengineered hair follicles work when using cells from the same species but have issues when combining human and mouse cells.

research Bioengineering the Hair Follicle

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Bioengineering can potentially treat hair loss by regenerating hair follicles and cloning hair, but the process is complex and needs more research.

research Hair Follicle Dermal Cells Differentiate Into Adipogenic and Osteogenic Lineages

268 citations , December 2003 in “Experimental Dermatology”

Hair follicle cells can become fat and bone cells.

Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

research Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

208 citations , December 2003 in “Journal of Investigative Dermatology”

Certain cells from hair follicles can create new hair and contribute to hair growth when implanted in mice.

research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

949 citations , January 2001 in “Cell”

Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.

research The Secret Life of the Hair Follicle

745 citations , February 1992 in “Trends in genetics”

Hair follicles create different cell layers and proteins, controlled by various molecules.

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