Induced Pluripotent Stem Cells From Human Hair Follicle Mesenchymal Stem Cells

    December 2012 in “ Stem Cell Reviews and Reports ”
    Yimei Wang, Jinyu Liu, Xiaohua Tan, Gaofeng Li, Yunhe Gao, Xuejuan Liu, Lihong Zhang, Yulin Li
    TLDR Human hair follicle cells can be turned into stem cells similar to embryonic stem cells.
    The study demonstrated that mesenchymal stem cells derived from human hair follicles (hHF-MSCs) could be successfully reprogrammed into inducible pluripotent stem cells (iPSCs) using lentiviral transduction with factors Oct4, Sox2, c-Myc, and Klf4. These hHF-MSC-derived iPSCs were shown to be similar to human embryonic stem cells in terms of colony morphology and expression of specific surface markers and genes. Additionally, when injected into immunocompromised mice, these iPSCs formed teratomas containing all three germ layers, confirming their pluripotency. This was the first study to report the reprogramming of hHF-MSCs into iPSCs, offering a potential alternative to using embryonic stem cells.
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