TLDR Human hair follicle cells can be turned into stem cells similar to embryonic stem cells.
The study demonstrated that mesenchymal stem cells derived from human hair follicles (hHF-MSCs) could be successfully reprogrammed into inducible pluripotent stem cells (iPSCs) using lentiviral transduction with factors Oct4, Sox2, c-Myc, and Klf4. These hHF-MSC-derived iPSCs were shown to be similar to human embryonic stem cells in terms of colony morphology and expression of specific surface markers and genes. Additionally, when injected into immunocompromised mice, these iPSCs formed teratomas containing all three germ layers, confirming their pluripotency. This was the first study to report the reprogramming of hHF-MSCs into iPSCs, offering a potential alternative to using embryonic stem cells.
26 citations
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February 2012 in “Journal of Investigative Dermatology” Human hair follicle cells can be successfully transformed into different types of cells, but not more efficiently than other adult cells.
131 citations
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July 2009 in “Experimental Dermatology” The document concludes that specific cells are essential for hair growth and more research is needed to understand how to maintain their hair-inducing properties.
788 citations
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February 2007 in “Nature” The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.
151 citations
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February 2006 in “Stem Cells and Development” Hair follicles can be a good source of stem cells like those from bone marrow.
38 citations
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April 2005 in “Journal of Investigative Dermatology”
28 citations
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August 2015 in “Journal of functional biomaterials” Cell-based therapies show promise for treating Limbal Stem Cell Deficiency but need more research.
17 citations
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February 2019 in “PubMed” Stem cells can help regenerate hair follicles.
74 citations
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January 2013 in “Expert Opinion on Biological Therapy” The conclusion is that hair growth can be improved by activating hair cycles, changing the surrounding environment, healing wounds to create new hair follicles, and using stem cell technology.
14 citations
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November 2020 in “International Journal of Molecular Sciences” Advanced therapies like gene, cell, and tissue engineering show promise for hair regrowth in alopecia, but their safety and effectiveness need more verification.
6 citations
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January 2015 in “Journal of regenerative medicine & tissue engineering” The review concludes that innovations in regenerative medicine, tissue engineering, and developmental biology are essential for effective tissue repair and organ transplants.
