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GlossarySOX2

gene crucial for stem cell pluripotency and tissue development

SOX2 is a gene that plays a crucial role in maintaining the self-renewal and pluripotency of stem cells, meaning it helps stem cells stay in a state where they can develop into different types of cells. It is also involved in the development of various tissues, including the nervous system and hair follicles, making it significant in both regenerative medicine and understanding conditions like alopecia.

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research Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis

338 citations , July 2009 in “Development”

research The Disruption of Sox21-Mediated Hair Shaft Cuticle Differentiation Causes Cyclic Alopecia in Mice

73 citations , May 2009 in “Proceedings of the National Academy of Sciences”

Disrupting the Sox21 gene in mice causes hair loss and regrowth cycles.

Clonal Growth of Dermal Papilla Cells in Hydrogels Reveals Intrinsic Differences Between Sox2-Positive and Sox2-Negative Cells In Vitro and In Vivo

research Clonal Growth of Dermal Papilla Cells in Hydrogels Reveals Intrinsic Differences Between Sox2-Positive and Sox2-Negative Cells In Vitro and In Vivo

68 citations , December 2011 in “Journal of Investigative Dermatology”

Sox2-positive dermal papilla cells have unique characteristics and contribute more to skin and hair follicle formation than Sox2-negative cells.

research Sox21 Regulates Anapc10 Expression and Determines the Fate of Ectodermal Organs

22 citations , June 2020 in “iScience”

Sox21 is crucial for tooth development and enamel formation by preventing cells from changing into a different type.

research Skipping a Hurdle: Sox2 and Adult Dermal Stem Cells

11 citations , December 2009 in “Cell stem cell”

Sox2-expressing cells can help grow hair and heal skin.

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