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GlossarySOX2

gene crucial for stem cell pluripotency and tissue development

SOX2 is a gene that plays a crucial role in maintaining the self-renewal and pluripotency of stem cells, meaning it helps stem cells stay in a state where they can develop into different types of cells. It is also involved in the development of various tissues, including the nervous system and hair follicles, making it significant in both regenerative medicine and understanding conditions like alopecia.

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research Scoparone Induces Expression of Pluripotency Transcription Factors SOX2 and NANOG in Dermal Papilla Cells

4 citations, January 2021 in “in Vivo”

Scoparone may help stimulate hair growth by increasing stem cell-related proteins in skin cells.

research Generation of Trichogenic Adipose-Derived Stem Cells by Expression of Three Factors

12 citations, August 2018 in “Journal of Dermatological Science”

Scientists made stem cells that can grow hair by adding three specific factors to them.

research SOX2 in the Skin: Roles in Biology and Pathology

1 citations, September 2015 in “Elsevier eBooks”

SOX2 is crucial for skin cell function and hair growth, and it plays a role in skin cancer and wound healing.

Supplementary Material for: Metformin Promotes the Hair-Inductive Activity of Three-Dimensional Aggregates of Epidermal and Dermal Cells Self-Assembled In Vitro

research Supplementary Material for: Metformin Promotes the Hair-Inductive Activity of Three-Dimensional Aggregates of Epidermal and Dermal Cells Self-Assembled In Vitro

January 2021 in “Figshare”

Metformin helps regenerate hair follicles in lab conditions.

Keratin 75 Is a Component of the LINC Complex and Has an Essential Role in Mediating the SOX2 Rapid Healing Response During Wound Repair

research Keratin 75 Is a Component of the LINC Complex and Has an Essential Role in Mediating the SOX2 Rapid Healing Response During Wound Repair

3 citations, September 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Keratin 75 is important for fast wound healing and works with SOX2 and the LINC complex to help skin cells move and repair damage.

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