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GlossarySOX2

gene crucial for stem cell pluripotency and tissue development

SOX2 is a gene that plays a crucial role in maintaining the self-renewal and pluripotency of stem cells, meaning it helps stem cells stay in a state where they can develop into different types of cells. It is also involved in the development of various tissues, including the nervous system and hair follicles, making it significant in both regenerative medicine and understanding conditions like alopecia.

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Nerve Dependence in Tissue, Organ, and Appendage Regeneration

research Nerve Dependence in Tissue, Organ, and Appendage Regeneration

228 citations , September 2012 in “Trends in Neurosciences”

Nerves are crucial for the regeneration of various body parts in many animals.

HaCaT-Conditioned Medium Supplemented with Small Molecule Inhibitors SB431542 and CHIR99021 and Growth Factor PDGF-AA Prevents the Dedifferentiation of Dermal Papilla Cells In Vitro

research HaCaT-Conditioned Medium Supplemented with Small Molecule Inhibitors SB431542 and CHIR99021 and Growth Factor PDGF-AA Prevents the Dedifferentiation of Dermal Papilla Cells In Vitro

7 citations , March 2021 in “Molecular Medicine Reports”

A mix of specific inhibitors and a growth factor helps keep hair growth cells from losing their properties in the lab.

Induced Pluripotent Stem Cells From Human Hair Follicle Mesenchymal Stem Cells

research Induced Pluripotent Stem Cells From Human Hair Follicle Mesenchymal Stem Cells

64 citations , December 2012 in “Stem Cell Reviews and Reports”

Human hair follicle cells can be turned into stem cells similar to embryonic stem cells.

$Human Keratinocytes Derived from the Bulge Region of Hair Follicles Are Refractory to Differentiation$

research Human Keratinocytes Derived from the Bulge Region of Hair Follicles Are Refractory to Differentiation

8 citations , April 2009 in “International journal of oncology”

Hair follicle cells resist turning into skin cells.

Induced Pluripotent Stem Cells from Human Hair Follicle Keratinocytes as a Potential Source for In Vitro Hair Follicle Cloning

research Induced Pluripotent Stem Cells from Human Hair Follicle Keratinocytes as a Potential Source for In Vitro Hair Follicle Cloning

November 2016

Human hair follicle cells can be turned into stem cells that may help clone hair for treating hair loss or burns.

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