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GlossarySOX2

gene crucial for stem cell pluripotency and tissue development

SOX2 is a gene that plays a crucial role in maintaining the self-renewal and pluripotency of stem cells, meaning it helps stem cells stay in a state where they can develop into different types of cells. It is also involved in the development of various tissues, including the nervous system and hair follicles, making it significant in both regenerative medicine and understanding conditions like alopecia.

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Clonal Growth of Dermal Papilla Cells in Hydrogels Reveals Intrinsic Differences Between Sox2-Positive and Sox2-Negative Cells In Vitro and In Vivo

research Clonal Growth of Dermal Papilla Cells in Hydrogels Reveals Intrinsic Differences Between Sox2-Positive and Sox2-Negative Cells In Vitro and In Vivo

68 citations, December 2011 in “Journal of Investigative Dermatology”

Sox2-positive dermal papilla cells have unique characteristics and contribute more to skin and hair follicle formation than Sox2-negative cells.

research Sox21 Regulates Anapc10 Expression and Determines the Fate of Ectodermal Organs

22 citations, July 2020 in “iScience”

Sox21 is crucial for tooth development and enamel formation by preventing cells from changing into a different type.

research Skipping a Hurdle: Sox2 and Adult Dermal Stem Cells

11 citations, December 2009 in “Cell stem cell”

Sox2-expressing cells can help grow hair and heal skin.

research Sox2 in the Dermal Papilla Regulates Hair Follicle Pigmentation

9 citations, July 2022 in “Cell reports”

Sox2 controls hair color by affecting pigment production in hair follicles.

research Scoparone Induces Expression of Pluripotency Transcription Factors SOX2 and NANOG in Dermal Papilla Cells

4 citations, January 2021 in “in Vivo”

Scoparone may help stimulate hair growth by increasing stem cell-related proteins in skin cells.

Keratin 75 Is a Component of the LINC Complex and Has an Essential Role in Mediating the SOX2 Rapid Healing Response During Wound Repair

research Keratin 75 Is a Component of the LINC Complex and Has an Essential Role in Mediating the SOX2 Rapid Healing Response During Wound Repair

3 citations, September 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Keratin 75 is important for fast wound healing and works with SOX2 and the LINC complex to help skin cells move and repair damage.

research SOX2 in the Skin: Roles in Biology and Pathology

1 citations, September 2015 in “Elsevier eBooks”

SOX2 is crucial for skin cell function and hair growth, and it plays a role in skin cancer and wound healing.

research A Low Dose of Rapamycin Promotes Hair Cell Differentiation by Enriching SOX2+ Progenitors in Neonatal Mouse Inner Ear Organoids

March 2024 in “PubMed”

A low dose of rapamycin increases inner ear hair cell creation by boosting SOX2+ cell numbers.

Transcription Factor SOX2-Induced Amphiregulin Inhibits Pressure Ulcer Formation via Suppressing Oxidative Stress After Cutaneous Ischemia-Reperfusion in Mice

research Transcription Factor SOX2-Induced Amphiregulin Inhibits Pressure Ulcer Formation via Suppressing Oxidative Stress After Cutaneous Ischemia-Reperfusion in Mice

April 2023 in “Journal of Investigative Dermatology”

SOX2 helps reduce wound size and pressure ulcer formation by suppressing oxidative stress and increasing antioxidant activity in mice.

research Study on Effect of Constant-Release Melatonin on SOX21 Gene

January 2011 in “China Animal Husbandry & Veterinary Medicine”

Constant-release melatonin reduces SOX21 gene expression in goats during the hair follicle resting phase.

research Nerve Dependence in Tissue, Organ, and Appendage Regeneration

228 citations, September 2012 in “Trends in Neurosciences”

Nerves are crucial for the regeneration of various body parts in many animals.

Cartilage to Bone Transformation During Fracture Healing Is Coordinated by the Invading Vasculature and Induction of the Core Pluripotency Genes

research Cartilage to Bone Transformation During Fracture Healing Is Coordinated by the Invading Vasculature and Induction of the Core Pluripotency Genes

160 citations, January 2017 in “Development”

Blood vessels and specific genes help turn cartilage into bone when bones heal.

research MicroRNA-302 Increases Reprogramming Efficiency via Repression of NR2F2

123 citations, November 2012 in “Stem cells”

MicroRNA-302 helps improve the conversion of body cells into stem cells by blocking NR2F2.

research Platelet-Derived Growth Factor Signaling Modulates Adult Hair Follicle Dermal Stem Cell Maintenance and Self-Renewal

37 citations, April 2017 in “npj Regenerative Medicine”

PDGF signaling is crucial for maintaining and renewing hair follicle stem cells, which could help treat hair loss.

research Fate of Prominin-1 Expressing Dermal Papilla Cells During Homeostasis, Wound Healing, and Wnt Activation

32 citations, August 2015 in “Journal of Investigative Dermatology”

Prominin-1 expressing cells in the dermal papilla help regulate hair follicle size and communication but don't aid in skin repair.

research Hair Follicle Dermal Stem Cells and Skin-Derived Precursor Cells: Exciting Tools for Endogenous and Exogenous Therapies

30 citations, April 2017 in “Experimental Dermatology”

Hair follicle stem cells and skin cells show promise for hair and skin therapies but need more research for clinical use.

PBX Homeobox 1 Enhances Hair Follicle Mesenchymal Stem Cell Proliferation and Reprogramming Through Activation of the AKT/Glycogen Synthase Kinase Signaling Pathway and Suppression of Apoptosis

research PBX Homeobox 1 Enhances Hair Follicle Mesenchymal Stem Cell Proliferation and Reprogramming Through Activation of the AKT/Glycogen Synthase Kinase Signaling Pathway and Suppression of Apoptosis

26 citations, August 2019 in “Stem Cell Research & Therapy”

PBX1 helps hair stem cells grow and change by turning on certain cell signals and preventing cell death, which may be useful for hair regrowth treatments.

research Getting to the Core of the Dermal Papilla

21 citations, October 2017 in “Journal of Investigative Dermatology”

The document concludes that understanding dermal papilla cells is key to improving hair regeneration treatments.

research Induced Pluripotent Stem Cells From Human Hair Follicle Keratinocytes As A Potential Source For In Vitro Hair Follicle Cloning

18 citations, November 2016 in “PeerJ”

Human hair follicles can be used to create stem cells that might help clone hair for treating hair loss or helping burn patients.

research Novel In Vitro Culture Condition Improves the Stemness of Human Dermal Stem/Progenitor Cells

18 citations, November 2013 in “Molecules and Cells”

New culture method keeps human skin stem cells more stem-like.

research Generation of iPS Cells from Human Hair Follicle Dermal Papilla Cells

15 citations, March 2014 in “Acta naturae”

Researchers made stem cells from human hair follicle cells with higher efficiency than from skin cells.

research Generation of Trichogenic Adipose-Derived Stem Cells by Expression of Three Factors

12 citations, August 2018 in “Journal of Dermatological Science”

Scientists made stem cells that can grow hair by adding three specific factors to them.

research Enrichment and Characterization of Human Dermal Stem/Progenitor Cells by Intracellular Granularity

10 citations, January 2013 in “Stem Cells and Development”

Scientists identified a unique type of human skin stem cell that could help with tissue repair.

research Human Long-Term Deregulated Circadian Rhythm Alters Regenerative Properties of Skin and Hair Precursor Cells

9 citations, July 2018 in “European journal of dermatology/EJD. European journal of dermatology”

Disrupted sleep patterns can harm skin and hair cell renewal, but melatonin might help.

research Effect of Laser Diode Light Irradiation on Growth Capability of Human Hair Follicle Dermal Papilla Cells

8 citations, July 2017

Laser diode light boosts hair follicle cell growth and certain gene expressions.

$Human Keratinocytes Derived from the Bulge Region of Hair Follicles Are Refractory to Differentiation$

research Human Keratinocytes Derived from the Bulge Region of Hair Follicles Are Refractory to Differentiation

8 citations, April 2009 in “International journal of oncology”

Hair follicle cells resist turning into skin cells.

HaCaT-Conditioned Medium Supplemented with Small Molecule Inhibitors SB431542 and CHIR99021 and Growth Factor PDGF-AA Prevents the Dedifferentiation of Dermal Papilla Cells In Vitro

research HaCaT-Conditioned Medium Supplemented with Small Molecule Inhibitors SB431542 and CHIR99021 and Growth Factor PDGF-AA Prevents the Dedifferentiation of Dermal Papilla Cells In Vitro

7 citations, March 2021 in “Molecular Medicine Reports”

A mix of specific inhibitors and a growth factor helps keep hair growth cells from losing their properties in the lab.

Secretory Phospholipase A2-IIA Overexpressing Mice Exhibit Cyclic Alopecia Mediated Through Aberrant Hair Shaft Differentiation and Impaired Wound Healing Response

research Secretory Phospholipase A2-IIA Overexpressing Mice Exhibit Cyclic Alopecia Mediated Through Aberrant Hair Shaft Differentiation and Impaired Wound Healing Response

7 citations, September 2017 in “Scientific Reports”

Mice with too much sPLA₂-IIA have hair loss and poor wound healing due to abnormal hair growth and stem cell depletion.

research Activation of TLR3 Enhances Stemness and Immunomodulatory Properties of Periodontal Ligament Stem Cells

3 citations, December 2016 in “Springer eBooks”

Activating TLR3 improves the healing and immune properties of periodontal ligament stem cells.

research Changes in the Expression of Smooth Muscle Cell-Related Genes in Human Dermal Sheath Cup Cells Associated with the Treatment Outcome of Autologous Cell-Based Therapy for Male and Female Pattern Hair Loss

2 citations, June 2022 in “International Journal of Molecular Sciences”

Lower levels of certain genes in hair cells improve hair loss treatment outcomes.