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    Glossary SOX2

    gene crucial for stem cell pluripotency and tissue development

    SOX2 is a gene that plays a crucial role in maintaining the self-renewal and pluripotency of stem cells, meaning it helps stem cells stay in a state where they can develop into different types of cells. It is also involved in the development of various tissues, including the nervous system and hair follicles, making it significant in both regenerative medicine and understanding conditions like alopecia.

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    Research 30 of 740

    1. Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis Development · 2009 · 338 citations
    2. The disruption of Sox21-mediated hair shaft cuticle differentiation causes cyclic alopecia in mice Proceedings of the National Academy of Sciences · 2009 · 73 citations
    3. Clonal Growth of Dermal Papilla Cells in Hydrogels Reveals Intrinsic Differences between Sox2-Positive and -Negative Cells In Vitro and In Vivo Journal of Investigative Dermatology · 2011 · 68 citations
    4. Sox21 Regulates Anapc10 Expression and Determines the Fate of Ectodermal Organ iScience · 2020 · 22 citations
    5. SKPing a Hurdle: Sox2 and Adult Dermal Stem Cells Cell stem cell · 2009 · 11 citations
    6. Sox2 in the dermal papilla regulates hair follicle pigmentation Cell reports · 2022 · 9 citations
    7. Scoparone Induces Expression of Pluripotency Transcription Factors SOX2 and NANOG in Dermal Papilla Cells in Vivo · 2021 · 4 citations
    8. Keratin 75 Is a Component of the LINC Complex and Has an Essential Role in Mediating the SOX2 Rapid Healing Response during Wound Repair 2022 · 3 citations
    9. SOX2 in the Skin Elsevier eBooks · 2015 · 1 citations
    10. A Low Dose of Rapamycin Promotes Hair Cell Differentiation by Enriching SOX2+ Progenitors in the Neonatal Mouse Inner Ear Organoids. PubMed · 2024
    11. 1496 Transcription factor SOX2-induced amphiregulin inhibits pressure ulcer formation via suppressing oxidative stress after cutaneous ischemia-reperfusion in mice Journal of Investigative Dermatology · 2023
    12. Study on Effect of Constant-release Melatonin on SOX21 Gene China Animal Husbandry & Veterinary Medicine · 2011
    13. Role of the SOX family in cancer immune evasion: Emerging player and promising therapeutic opportunities Medicine · 2025 · 1 citations
    14. Major depletion of SOX2+ stem cells in the adult pituitary is not restored which does not affect hormonal cell homeostasis and remodelling Scientific Reports · 2017 · 22 citations
    15. Nerve dependence in tissue, organ, and appendage regeneration Trends in Neurosciences · 2012 · 228 citations
    16. Cartilage to bone transformation during fracture healing is coordinated by the invading vasculature and induction of the core pluripotency genes Development · 2017 · 160 citations
    17. MicroRNA-302 Increases Reprogramming Efficiency via Repression of NR2F2 Stem cells · 2012 · 123 citations
    18. Dynamic Plasticity of Axons within a Cutaneous Milieu Journal of Neuroscience · 2010 · 79 citations
    19. Induced Pluripotent Stem Cells from Human Hair Follicle Mesenchymal Stem Cells Stem Cell Reviews and Reports · 2012 · 64 citations
    20. Preconditioning with far-infrared irradiation enhances proliferation, cell survival, and migration of rat bone marrow-derived stem cells via CXCR4-ERK pathways Scientific Reports · 2017 · 44 citations
    21. Platelet-derived growth factor signaling modulates adult hair follicle dermal stem cell maintenance and self-renewal npj Regenerative Medicine · 2017 · 37 citations
    22. Fate of Prominin-1 Expressing Dermal Papilla Cells during Homeostasis, Wound Healing and Wnt Activation Journal of Investigative Dermatology · 2015 · 32 citations
    23. Hair follicle dermal stem cells and skin‐derived precursor cells: Exciting tools for endogenous and exogenous therapies Experimental Dermatology · 2017 · 30 citations
    24. PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis Stem Cell Research & Therapy · 2019 · 26 citations
    25. Getting to the Core of the Dermal Papilla Journal of Investigative Dermatology · 2017 · 21 citations
    26. Glycyrrhizic acid attenuates stem cell-like phenotypes of human dermal papilla cells Phytomedicine · 2015 · 21 citations
    27. Induced pluripotent stem cells from human hair follicle keratinocytes as a potential source for <i>in vitro</i> hair follicle cloning PeerJ · 2016 · 18 citations
    28. Novel in vitro culture condition improves the stemness of human dermal stem/progenitor cells Molecules and Cells · 2013 · 18 citations
    29. Lithium chloride promotes the odontoblast differentiation of hair follicle neural crest cells by activating Wnt/β‐catenin signaling Cell Biology International · 2014 · 16 citations
    30. Generation of iPS Cells from Human Hair Follice Dermal Papilla Cells Acta naturae · 2014 · 15 citations