PBX Homeobox 1 Enhances Hair Follicle Mesenchymal Stem Cell Proliferation and Reprogramming Through Activation of the AKT/Glycogen Synthase Kinase Signaling Pathway and Suppression of Apoptosis
August 2019
in “
Stem Cell Research & Therapy
”
PBX homeobox 1 PBX1 hair follicle mesenchymal stem cells HF-MSCs induced pluripotent stem cells iPSCs AKT glycogen synthase kinase GSK3B β-catenin pluripotency genes Nanog SOX2 OCT4 apoptosis hair follicle regeneration hair loss therapy stem cells pluripotent stem cells AKT pathway GSK3B pathway beta-catenin pluripotency hair regeneration hair loss treatment
TLDR PBX1 helps hair stem cells grow and change by turning on certain cell signals and preventing cell death, which may be useful for hair regrowth treatments.
The 2019 study by Jiang et al. demonstrated that PBX homeobox 1 (PBX1) significantly enhances the proliferation and reprogramming of hair follicle mesenchymal stem cells (HF-MSCs) into induced pluripotent stem cells (iPSCs). PBX1 overexpression activated the AKT/glycogen synthase kinase (GSK) 3B signaling pathway, increased phosphorylation of AKT, and promoted nuclear translocation of β-catenin, leading to cell cycle progression and increased formation of alkaline phosphatase-stained colonies. It also upregulated pluripotency genes such as Nanog, SOX2, and OCT4, and reduced apoptosis during the early stages of reprogramming. Conversely, inhibition of PBX1 or phospho-AKT resulted in increased apoptosis and reduced reprogramming efficiency. The study concluded that PBX1 is crucial for HF-MSC proliferation and reprogramming by activating the AKT/GSK3ß pathway and suppressing apoptosis, suggesting its potential in hair follicle regeneration and hair loss therapy. The number of participants or samples used in the study was not mentioned in the summary.
