Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated With Upregulation of Cyclin D1 and Downregulation of p16
October 2016
in “
Stem Cells and Development
”
TLDR Epidermal growth factor helps hair stem cells grow by activating specific cell pathways.
The study demonstrated that epidermal growth factor (EGF) significantly enhanced the proliferation of hair follicle-derived mesenchymal stem cells (HF-MSCs) while maintaining their ability to differentiate into multiple cell types. This proliferation was mediated through the activation of the EGFR/ERK and AKT signaling pathways, but not the STAT-3 pathway. EGF promoted the transition of HF-MSCs from the G1 phase to the S and G2 phases of the cell cycle by upregulating cyclin D1 and inhibiting p16 expression. The use of specific inhibitors confirmed the involvement of these pathways in EGF-induced proliferation.
