Multipotent Nestin-Positive, Keratin-Negative Hair-Follicle Bulge Stem Cells Can Form Neurons

    March 2005 in “ Proceedings of the National Academy of Sciences ”
    Yasuyuki Amoh, Lingna Li, Kensei Katsuoka, Sheldon Penman, Robert M. Hoffman
    TLDR Hair-follicle stem cells can become neurons.
    The study demonstrated that nestin-positive, keratin-negative stem cells from the hair-follicle bulge area in transgenic mice could differentiate into various cell types, including neurons, glia, keratinocytes, smooth muscle cells, and melanocytes in vitro. These stem cells, marked by ND-GFP and CD34 positivity, were shown to be in a relatively undifferentiated state, indicating their pluripotency. Additionally, when transplanted into the subcutis of nude mice, these cells could differentiate into neurons. The findings suggested that these hair-follicle bulge-area stem cells might serve as an accessible and autologous source of multipotent stem cells for therapeutic applications.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    4 / 4 results

      community New Treatments, and a Huge Group Buy with Lots of Research

      in Research/Science  109 upvotes 2 years ago
      A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

      community Please explain this Minoxidil phenomena

      in Minoxidil  58 upvotes 2 years ago
      The post discusses the difference in effects of Minoxidil (Min) on scalp and facial hair. The user questions why Min-induced hair growth on the scalp is temporary, while facial hair growth seems permanent, even after stopping Min. They propose theories, including different Min mechanisms on body and facial hair, the role of DHT, and the possibility of not achieving fully terminal hair. The responses include personal experiences and theories about Min's effects on hair growth.

      community Fats on your Head to Stop Hair Loss?

      in Research/Science  138 upvotes 1 year ago
      The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

      community One full year progress on fin + min

      in Progress Pictures  517 upvotes 1 year ago
      A user shared their one-year progress using finasteride and minoxidil for hair loss, showing significant improvement. They also mentioned using the medication inconsistently and considering changes to their shampoo routine.

    Similar Research

    5 / 497 results