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    Glossary Smooth Muscle Cells

    Smooth muscle cells are non-striated, involuntary muscle cells found in various tissues throughout the body, including the dermal layer of the skin where hair follicles reside. They play a crucial role in regulating blood flow and the contraction of hair follicles, which can influence hair growth and loss. In the context of hair biology, the contraction of these cells can affect the hair's position and the cycle of hair growth, making them relevant in understanding conditions like alopecia and other hair loss disorders. Key distinguishing characteristics of smooth muscle cells include their spindle-shaped structure and the ability to contract slowly and rhythmically, unlike skeletal muscle cells.

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    1. Hair Follicle-Derived Smooth Muscle Cells and Small Intestinal Submucosa for Engineering Mechanically Robust and Vasoreactive Vascular Media Tissue Engineering Part A · 2010 · 50 citations
    2. Long-term Oral Administration of 5α-reductase Inhibitor Attenuates Erectile Function by Inhibiting Autophagy and Promoting Apoptosis of Smooth Muscle Cells in Corpus Cavernosum of Aged Rats Urology · 2013 · 34 citations
    3. Human hair follicle stem cell differentiation into contractile smooth muscle cells is induced by transforming growth factor-β1 and platelet-derived growth factor BB Molecular Medicine Reports · 2013 · 19 citations
    4. Changes in the Expression of Smooth Muscle Cell–Related Genes in Human Dermal Sheath Cup Cells Associated with the Treatment Outcome of Autologous Cell–Based Therapy for Male and Female Pattern Hair Loss International Journal of Molecular Sciences · 2022 · 2 citations
    5. Smooth muscle cell expression of a constitutive active form of human Profilin1 accelerates cutaneous wound repair The FASEB Journal · 2011
    6. Minoxidil Stimulates Elastin Expression in Aortic Smooth Muscle Cells Archives of Biochemistry and Biophysics · 1994 · 33 citations
    7. Multiple congenital smooth muscle hamartoma: A case report Dermatologica Sinica · 2024
    8. Multipotent nestin-positive, keratin-negative hair-follicle bulge stem cells can form neurons Proceedings of the National Academy of Sciences · 2005 · 419 citations
    9. Isolation of a Novel Population of Multipotent Adult Stem Cells from Human Hair Follicles American Journal Of Pathology · 2006 · 344 citations
    10. Cellular actions of testosterone in vascular cells: Mechanism independent of aromatization to estradiol Steroids · 2012 · 55 citations
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    1. Minoxidil Vasodilator used on the scalp and, at low doses, as a tablet

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