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Glossary Alpha-smooth muscle actin

protein involved in smooth muscle contraction and wound healing

Alpha-smooth muscle actin (α-SMA) is a protein that plays a crucial role in the contraction of smooth muscle cells, which are found in various tissues like blood vessels and the digestive tract. It is also a marker used by scientists to identify myofibroblasts, cells involved in wound healing and tissue repair. Elevated levels of α-SMA can indicate tissue remodeling or fibrosis, which is the thickening and scarring of connective tissue.

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research Formation of actin mesh structures and alpha-smooth muscle actin dynamics in fibroblasts contribute to dermal regeneration in mouse fetus

1 citations , September 2025 in “PLoS ONE”

This study observed that in mouse fetuses, reticular contraction by actomyosin is involved in dermal regeneration, and differences in actin and α-SMA localization may determine the switch between regeneration and scar formation, suggesting potential insights for wound regeneration therapy.

research Alpha Smooth Muscle Actin role in Androgenetic Alopecia Pathogenesis:

November 2024 in “Benha Journal of Applied Sciences”

In this study, the researchers explored how the loss of structural integrity in hair follicles due to reduced α-SMA expression in the vertex area may contribute to androgenetic alopecia.

research Generation and Characterization of Multipotent Stem Cells from Established Dermal Cultures

58 citations , November 2012 in “PLoS ONE”

This study found that dermal fibroblast cultures, especially those with higher alpha-smooth muscle actin expression, can be used to produce skin-derived precursor cells, unlike human hair follicle dermal papilla cultures.

research The repairing of full-thickness skin deficiency and its biological mechanism using decellularized human amniotic membrane as the wound dressing

47 citations , March 2017 in “Materials Science and Engineering: C”

In this study, decellularized human amniotic membrane was found to promote wound healing and reduce scar formation in rats with full-thickness skin defects, compared to traditional clinical treatments.

research A novel immune competent murine hypertrophic scar contracture model: A tool to elucidate disease mechanism and develop new therapies

35 citations , October 2014 in “Wound Repair and Regeneration”

This study developed a validated murine model of hypertrophic scar contraction, demonstrating similarities to human skin and observing graft contraction and tissue characteristics over time.

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community Finasteride Doubled my Total & Free Test but also my Estradiol - 8 months in

in Chat 32 upvotes 1 month ago

A 22-year-old male experienced increased testosterone and estradiol levels after 8 months on finasteride, leading to softer erections and reduced arousal. Suggestions included reducing finasteride dosage, using supplements like L-arginine, L-citrulline, zinc, and possibly tadalafil to improve symptoms.

community Is this real chat? Finasteride -> fountain of youth and longevity drug?

559 upvotes 1 year ago

Finasteride is discussed as a hair loss treatment with benefits like reduced prostate enlargement and skin aging, but it is not seen as a "fountain of youth." Users report mixed experiences, including side effects like decreased libido and dry eyes.

community Research Backed Dutasteride Simulator (Serum/Scalp DHT included for all doses)

116 upvotes 1 year ago

A dutasteride simulator predicts that daily 0.5 mg dosing results in higher DHT suppression compared to less frequent dosing. Twice-weekly dutasteride may be as effective as finasteride 5 mg, providing a balance between efficacy and ease of use.

community Be careful when switching from Finasteride to Dutasteride because for more efficacy.

in Finasteride/Dutasteride 13 upvotes 1 year ago

Switching from finasteride to dutasteride may be more effective for hair regrowth due to dutasteride's stronger enzyme inhibition, but combining both drugs could enhance results. Some users report better outcomes with dutasteride, while others recommend a gradual transition to prevent potential hair loss.

community Finasteride can revive up to 7 year old dead hair

in Research/Science 188 upvotes 1 year ago

Finasteride and minoxidil can revive hair dormant for up to 7 years, with microneedling enhancing regrowth. Users report significant hair regrowth even after long periods of baldness.

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signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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