Effects of Ginsenoside Rb1 on Hypertrophic Scar Remodeling in Rabbit Model

The study investigated the effects of ginsenoside Rb1 on hypertrophic scar remodeling in a rabbit model. A total of 72 hypertrophic scars were generated on the ears of six New Zealand white rabbits and treated with various doses of ginsenoside Rb1. The highest dose (0.56 mg) significantly reduced scar elevation and improved collagen arrangement, resembling normal dermis. Ginsenoside Rb1 also decreased the expression of profibrotic proteins and growth factors (MMP2, TIMP1, α-SMA, and TGF-β1) and suppressed collagen type 1 expression. The findings suggested that ginsenoside Rb1 could be an effective therapeutic agent for hypertrophic scar treatment, with the highest efficacy observed at the 0.56 mg dosage. Further research was recommended to optimize application and exposure conditions.