Combination of Lyophilized Adipose-Derived Stem Cell Concentrated Conditioned Medium and Polysaccharide Hydrogel in the Inhibition of Hypertrophic Scarring

January 2021 in “ Stem Cell Research & Therapy ”

Chaoyu Zhang, Ting Wang, Li Zhang, Penghong Chen, Shijie Tang, Aizhen Chen, Ming Li, Guohao Peng, Hangqi Gao, Haiyan Weng, Haoruo Zhang, Shirong Li, Jinghua Chen, Liangwan Chen, Xiaosong Chen

adipose-derived stem cell conditioned medium polysaccharide hydrogel hypertrophic scarring α-smooth muscle actin anti-fibrosis cytokine release

Studysummary This study found that incorporating adipose-derived stem cell conditioned medium into a polysaccharide hydrogel effectively reduced scar hyperplasia, with the combination offering better outcomes in preventing hypertrophic scarring compared to the medium alone in a rabbit ear model.

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