Fibrous Scaffolds Potentiate the Paracrine Function of Mesenchymal Stem Cells: A New Dimension in Cell-Material Interaction

    June 2017 in “ Biomaterials ”
    Su Ni, Peng-Lai Gao, Kai Wang, Jinyang Wang, Yi Zhong, Ying Luo
    Image of study
    TLDR Special fiber materials boost the healing properties of certain stem cells.
    The study explored the impact of fibrous scaffold topography on the paracrine functions of adipose-derived mesenchymal stem cells (Ad-MSCs). It was discovered that scaffolds with different fiber orientations significantly increased the secretion of anti-inflammatory and pro-angiogenic cytokines by Ad-MSCs. The study demonstrated that the conditioned medium from Ad-MSCs cultured on these scaffolds had beneficial effects on endothelial cells and macrophages, and improved wound healing in a rat model. The in vitro assays involved 4 to 6 samples, while the in vivo wound healing experiments used 8 samples. The findings suggest that scaffold topography can be a critical factor in enhancing the therapeutic potential of MSCs for tissue repair and regeneration.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 7 results

      community 22 | ~34 Months Finasteride Update

      in Progress Pictures  818 upvotes 3 months ago
      A user shared their 34-month update on using finasteride for hair loss, noting they maintained regrowth even after stopping minoxidil a year ago. Other users shared similar experiences and expressed admiration for the results.

      community Verteporfin and Microneedling

      in Treatments 5 months ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

      community 5 years on Finasteride, 1.5 years on Minoxidil Foam

      in Progress Pictures  707 upvotes 9 months ago
      The user has been using finasteride for five years and minoxidil foam for 1.5 years to combat hair loss, experiencing significant regrowth after an initial shedding phase with minoxidil. They shared progress pictures and discussed treatment experiences, including the addition of minoxidil to their regimen after noticing reduced efficacy with finasteride alone.

    Related Research

    1 / 1 results