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Glossary Paracrine Function

cells communicate by releasing signals to nearby cells

Paracrine function refers to a type of cell signaling where a cell produces a signal to induce changes in nearby cells, affecting their behavior or function. Unlike hormones that travel through the bloodstream to distant targets, paracrine signals act locally, ensuring that the response is limited to the immediate cellular environment. This is crucial in processes like wound healing and immune responses.

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research Fibrous scaffolds potentiate the paracrine function of mesenchymal stem cells: A new dimension in cell-material interaction

182 citations , June 2017 in “Biomaterials”

This study found that adipose-derived mesenchymal stem cells produced more anti-inflammatory and pro-angiogenic cytokines on electrospun scaffolds, which enhanced wound healing and macrophage activity in a rat model.

research Effects of microenvironment and biological behavior on the paracrine function of stem cells

44 citations , April 2023 in “Genes & Diseases”

This review discusses the paracrine function of mesenchymal stem cells in tissue regeneration and repair, focusing on secreted bioactive substances and their role under different microenvironments; it reports no new clinical results.

research The topography of fibrous scaffolds modulates the paracrine function of Ad-MSCs in the regeneration of skin tissues

24 citations , January 2019 in “Biomaterials Science”

This study demonstrated that a bio-3D printed artificial skin scaffold, seeded with adipose-derived mesenchymal stem cells, showed promising wound healing properties by enhancing cell recruitment, migration, and gene expression related to tissue regeneration.

research Melatonin membrane receptors in peripheral tissues: Distribution and functions

506 citations , January 2012 in “Molecular and Cellular Endocrinology”

This review details the expression and diverse functions of melatonin receptors in non-neural tissues and reports no new clinical findings, emphasizing their potential as therapeutic targets across various physiological and pathological processes.

research Biomaterials Functionalized with MSC Secreted Extracellular Vesicles and Soluble Factors for Tissue Regeneration

220 citations , March 2020 in “Advanced functional materials”

This review discusses the mechanisms and potential therapeutic benefits of mesenchymal stromal cell-derived extracellular vesicles delivered via biomaterials, but reports no new clinical results.

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community How is dht not beneficial to you?

in Finasteride/Dutasteride 111 upvotes 7 months ago

DHT is important for sexual function and mood, but finasteride and dutasteride can reduce DHT, causing side effects like reduced libido and erectile dysfunction. These treatments are effective for hair loss, but their impact on DHT leads to debate.

community The mechanism of androgenic alopecia

36 upvotes 11 months ago

DHT may inhibit hair growth by affecting mitochondrial function, leading to hair follicle miniaturization. Treatments like minoxidil and PP405 may promote hair growth by altering metabolic pathways, potentially counteracting DHT's effects.

community Finasteride - impact on Neurosteroids, which yes, \are important and not a garbage hormone

in Research/Science 163 upvotes 1 year ago

Finasteride may affect neurosteroids, impacting mood and sexual function, with varied user experiences. Some report side effects like depression and sexual dysfunction, while others find it effective for hair retention or prefer alternatives like Dutasteride or topical treatments.

community What is the cause of "DHT itch"?

in Research/Science 7 upvotes 1 year ago

The conversation discusses the effects of using Tongkat ali and dioscorea to raise DHT levels, leading to increased body hair growth and an itchy scalp, without causing hair loss. The discussion also debates the role of DHT in male characteristics and its impact on sexual function, with differing opinions on its importance and effects.

community Dutasteride Isn't Working? Get a Scalp Biopsy NOW

in Finasteride/Dutasteride 19 upvotes 1 year ago

Dutasteride may not be effective for everyone due to underlying issues, suggesting scalp biopsies for further diagnosis. Users discuss using higher doses of dutasteride, topical treatments, minoxidil, and pyrilutamide for hair loss management.

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