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GlossaryParacrine Signaling

cells communicate by releasing molecules to nearby cells

Paracrine signaling is a form of cell-to-cell communication where a cell produces signaling molecules, such as growth factors or cytokines, that affect nearby target cells within the same tissue. Unlike endocrine signaling, which involves hormones traveling through the bloodstream to distant targets, paracrine signals act locally, ensuring a rapid and specific response in the immediate cellular environment. This type of signaling is crucial in processes like wound healing, immune responses, and hair follicle regulation.

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Androgen Receptor-Mediated Paracrine Signaling Induces Regression of Blood Vessels in the Dermal Papilla in Androgenetic Alopecia

research Androgen Receptor-Mediated Paracrine Signaling Induces Regression of Blood Vessels in the Dermal Papilla in Androgenetic Alopecia

6 citations, January 2022 in “Journal of Investigative Dermatology”

Male pattern baldness is linked to higher levels of a certain receptor in the scalp, which leads to the shrinking of blood vessels and hair loss. Early treatment targeting this receptor could be more effective.

research Rac-Dependent Signaling from Keratinocytes Promotes Differentiation of Intradermal White Adipocytes

1 citations, November 2018 in “bioRxiv (Cold Spring Harbor Laboratory)”

Signals from skin cells controlled by Rac proteins help turn certain precursor cells into white fat cells.

The Topography of Fibrous Scaffolds Modulates the Paracrine Function of Adipose-Derived Mesenchymal Stem Cells in the Regeneration of Skin Tissues

research The Topography of Fibrous Scaffolds Modulates the Paracrine Function of Adipose-Derived Mesenchymal Stem Cells in the Regeneration of Skin Tissues

24 citations, January 2019 in “Biomaterials Science”

The shape of fibrous scaffolds can improve how stem cells help heal skin.

research Emerging Nonmetabolic Functions of Skin Fat

65 citations, January 2018 in “Nature Reviews Endocrinology”

Skin fat has important roles in hair growth, skin repair, immune defense, and aging, and could be targeted for skin and hair treatments.

research The Role of Stem Cells in Cutaneous Wound Healing: What Do We Really Know?

43 citations, January 2011 in “Plastic and Reconstructive Surgery”

Stem cells have great potential for improving wound healing, but more research is needed to find the best types and ways to use them.

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community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 742 upvotes 2 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community Why is Minoxidil not enough for hair loss? (No fin)

in Minoxidil 59 upvotes 3 months ago

Minoxidil alone is often insufficient for treating hair loss because it doesn't address the DHT-related cause. Combining it with finasteride, a DHT blocker, is generally more effective.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 5 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community An argument for why we should take topical Dutasteride seriously

in Research/Science 85 upvotes 3 years ago

Topical Dutasteride may halt hair loss and effectively treat androgenic alopecia. Combining low-dose oral Dutasteride with topical application could maximize regrowth and minimize side effects.

community I started rapidly diffuse thinning at 22. I'm 42 now and have as much hair as I did at 16. AMA

in Treatment 443 upvotes 5 years ago

Hair loss treatments like finasteride, minoxidil, ketoconazole, PRP, and microneedling helped maintain hair for 20 years. Research and try evidence-based treatments for best results.

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