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To Control Site-Specific Skin Gene Expression, Autocrine Mimics Paracrine Canonical Wnt Signaling and Is Activated Ectopically in Skin Disease

research To Control Site-Specific Skin Gene Expression, Autocrine Mimics Paracrine Canonical Wnt Signaling and Is Activated Ectopically in Skin Disease

23 citations, May 2016 in “American Journal of Pathology”

The research suggests that a specific skin gene can be controlled by signals within and between cells and is wrongly activated in certain skin diseases.

research Suppression of Wnt/β-Catenin Signaling by EGF Receptor Is Required for Hair Follicle Development

25 citations, September 2018 in “Molecular Biology of the Cell”

Blocking Wnt/β-catenin signaling with EGF receptor is necessary for proper hair growth.

research Nonanal Stimulates Growth Factors via Cyclic Adenosine Monophosphate (cAMP) Signaling in Human Hair Follicle Dermal Papilla Cells

8 citations, October 2020 in “International Journal of Molecular Sciences”

Nonanal from fruits and vegetables promotes hair growth by increasing growth factors.

research FGF Family: From Drug Development to Clinical Application

103 citations, June 2018 in “International Journal of Molecular Sciences”

FGF signaling is a promising target for developing treatments for wounds, metabolic diseases, and cancer.

research Hedgehog Signaling Reprograms Hair Follicle Niche Fibroblasts to a Hyper-Activated State

25 citations, June 2022 in “Developmental cell”

Overactivating Hedgehog signaling makes hair follicle cells in mice grow hair faster and create more follicles.

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community Why HMI115 should work if it doesn’t affect dht?

in Research/Science 16 upvotes 1 year ago

Hair growth can be induced without stopping DHT, as seen with Minoxidil. HMI115 may work by promoting follicle growth, not targeting the root cause of hair loss (DHT).

community does lowering your prolactin levels regrow hair?

in Research/Science 9 upvotes 1 year ago

The potential of lowering prolactin levels to regrow hair, with a reference to Bayer's drug HMI 115 which has been indicated as having this effect. Treatments mentioned include Minoxidil and Finasteride, as well as RU58841.

community Does lowering serum prolactin lower prolactin in the scalp?

in Research/Science 13 upvotes 8 months ago

The conversation discusses whether not masturbating (semen retention) affects hair loss, with opinions varying but generally dismissing the idea. Some participants mention using hair loss treatments like Minoxidil, Finasteride, and RU58841, but the effectiveness and relation to prolactin levels in the scalp are debated.

community Two Great Articles on NCBI That Summarize What We Actually Know About Finasteride Side Effects

in Finasteride 80 upvotes 5 years ago

The side effects of taking finasteride as a treatment for hair loss, with particular focus on its sexual and psychiatric side effects; research has indicated that there are high and low outliers in terms of prevalence of sexual side effects, but it is usually between 3-5%, while evidence of lasting sexual side effects comes from lower quality sources.

community 5ARI (dutasteride) Associated with Adverse Metabolic Effects

23 upvotes 6 years ago

Dutasteride is associated with increased blood glucose, HbA1c, LDL cholesterol, and liver enzyme activity, potentially leading to diabetes, NAFLD, and liver metabolism changes. The conversation highlights concerns about these adverse effects and calls for more studies, including on finasteride.

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