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    Emerging Nonmetabolic Functions of Skin Fat

    January 2018 in “ Nature Reviews Endocrinology ”
    Christian F. Guerrero‐Juarez, Maksim V. Plikus
    Studysummary This review discusses the unique features of dermal white adipose tissue, its interaction with hair follicles, and its role in skin physiology, reporting no new experimental findings.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 39

    1. Adipocyte-Myofibroblast Transition as a Possible Pathophysiological Step in Androgenetic Alopecia Experimental Dermatology · 2017
    2. Repeal And Replace: Adipocyte Regeneration In Wound Repair Cell Stem Cell · 2017
    3. Regeneration of Fat Cells from Myofibroblasts During Wound Healing Science · 2017
    4. Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT Signaling Axis Cell Stem Cell · 2016
    5. Hair Follicles’ Transit-Amplifying Cells Govern Concurrent Dermal Adipocyte Production Through Sonic Hedgehog Genes & Development · 2016
    6. Skin Aging: Are Adipocytes the Next Target? Aging · 2016
    7. The Role of Adipocytes in Tissue Regeneration and Stem Cell Niches Annual Review of Cell and Developmental Biology · 2016
    8. Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis Science · 2016
    9. Epidermal β-Catenin Activation Remodels the Dermis via Paracrine Signaling to Distinct Fibroblast Lineages Nature Communications · 2016
    10. Dermal White Adipose Tissue: A New Component of the Thermogenic Response Journal of Lipid Research · 2015
    11. A Guide to Studying Human Hair Follicle Cycling In Vivo Journal of Investigative Dermatology · 2015
    12. Principles and Mechanisms of Regeneration in the Mouse Model for Wound-Induced Hair Follicle Neogenesis Regeneration · 2015
    13. Syndecan-1 Is Required to Maintain Intradermal Fat and Prevent Cold Stress PLOS genetics · 2014
    14. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014
    15. Defining Dermal Adipose Tissue Experimental Dermatology · 2014
    16. Epidermal Wnt/β-Catenin Signaling Regulates Adipocyte Differentiation via Secretion of Adipogenic Factors Proceedings of the National Academy of Sciences of the United States of America · 2014
    17. Regenerative Hair Waves in Aging Mice and Extra-Follicular Modulators Follistatin, Dkk1, and Sfrp4 Journal of Investigative Dermatology · 2014
    18. Macroenvironmental Regulation of Hair Cycling and Collective Regenerative Behavior Cold Spring Harbor Perspectives in Medicine · 2014
    19. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    20. Hair Cycle Control by Leptin as a New Anagen Inducer Experimental Dermatology · 2013
    21. Lipoatrophy and Severe Metabolic Disturbance in Mice with Fat-Specific Deletion of PPARγ Proceedings of the National Academy of Sciences of the United States of America · 2013
    22. Intradermal Adipocytes Mediate Fibroblast Recruitment During Skin Wound Healing Development · 2013
    23. Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration Journal of Investigative Dermatology · 2012
    24. Identification of Stem Cell Populations in Sweat Glands and Ducts Reveals Roles in Homeostasis and Wound Repair Cell · 2012
    25. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011
    26. Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells Cell stem cell · 2011
    27. Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells Science · 2011
    28. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    29. Analyses of Regenerative Wave Patterns in Adult Hair Follicle Populations Reveal Macro-Environmental Regulation of Stem Cell Activity ˜The œInternational journal of developmental biology · 2009
    30. Complex Hair Cycle Domain Patterns and Regenerative Hair Waves in Living Rodents Journal of Investigative Dermatology · 2007
    31. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    32. PDGF Isoforms Induce and Maintain Anagen Phase of Murine Hair Follicles Journal of Dermatological Science · 2006
    33. Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle PLoS biology · 2005
    34. Molecular Principles of Hair Follicle Induction and Morphogenesis BioEssays · 2005
    35. BMP Signaling in the Control of Skin Development and Hair Follicle Growth Differentiation · 2004
    36. Defining BMP Functions in the Hair Follicle by Conditional Ablation of BMP Receptor IA The Journal of Cell Biology · 2003
    37. Inhibition of BMP Signaling Affects Growth and Differentiation in the Anagen Hair Follicle The EMBO Journal · 2000
    38. Induction of the Hair Growth Phase in Postnatal Mice by Localized Transient Expression of Sonic Hedgehog Journal of Clinical Investigation · 1999
    39. Transforming Growth Factor-β Receptor Type I and Type II Expression During Murine Hair Follicle Development and Cycling Journal of Investigative Dermatology · 1997

    Related research 5

    1. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    2. Expression of Matrix Metalloproteinases and Tissue Inhibitor of Matrix Metalloproteinases in the Hair Cycle Experimental and Therapeutic Medicine · 2016
    3. Dermal Papilla-Derived Wnt Ligands Are Required for Adult Hair Follicle Growth Journal of Investigative Dermatology · 2016
    4. Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Investigative Dermatology · 2012
    5. Hair Follicle Expression of 1,25-Dihydroxyvitamin D3 Receptors During the Murine Hair Cycle British Journal of Dermatology · 2006