TLDR PDGF isoforms can promote and sustain hair growth.
The study explored the impact of PDGF-AA and PDGF-BB on hair growth in C3H mice, finding that these isoforms effectively induced and maintained the anagen phase of hair follicles, as shown by increased skin thickness and hair follicle activity. The role of PDGF in promoting hair growth was confirmed by the disruption of the anagen phase with anti-PDGF antibodies. Additionally, PDGF treatments upregulated key signaling molecules like Shh, Wnt5a, and Lef-1, suggesting that PDGF isoforms could be potential treatments for alopecia by promoting and sustaining hair growth.
55 citations
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September 2003 in “Experimental Dermatology” PDGF signaling may play a role in hair growth cycle regulation.
73 citations
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November 2000 in “Proceedings of the National Academy of Sciences of the United States of America” There are two ways to start hair growth: one needs Stat3 and the other does not, but both need PI3K activation.
231 citations
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October 1999 in “Journal of Clinical Investigation” Activating the Sonic hedgehog gene in mice can start the hair growth phase.
76 citations
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August 2018 in “International Journal of Cosmetic Science” Dermal Papilla cells are a promising tool for evaluating hair growth treatments.
21 citations
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April 2018 in “Journal of Dermatological Science” Cilostazol helps hair grow by making hair root cells grow faster and changing growth factor levels.
37 citations
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April 2017 in “npj Regenerative Medicine” PDGF signaling is crucial for maintaining and renewing hair follicle stem cells, which could help treat hair loss.
June 2024 in “Regenerative Therapy” Exosomes from stem cells may help rejuvenate skin and regrow hair, but more research is needed.
41 citations
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July 2012 in “Stem Cells and Development” Low-dose UVB light improves hair growth effects of certain stem cells by increasing reactive oxygen species.
