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GlossaryPlatelet-Derived Growth Factor BB (PDGF-BB)

protein that stimulates cell growth and tissue repair

Platelet-Derived Growth Factor BB (PDGF-BB) is a protein that plays a crucial role in cell growth, healing, and the formation of blood vessels. It is one of the isoforms of PDGF and is particularly important in wound healing and tissue repair, as it stimulates the proliferation and migration of cells such as fibroblasts and smooth muscle cells.

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Platelet-Derived Growth Factor Regulates the Proliferation and Differentiation of Human Melanocytes in a Differentiation-Stage-Specific Manner

research Platelet-Derived Growth Factor Regulates the Proliferation and Differentiation of Human Melanocytes in a Differentiation-Stage-Specific Manner

10 citations, May 2016 in “Journal of Dermatological Science”

PDGF-BB helps young melanocytes grow but stops mature ones from growing, and it makes melanocytes more specialized.

research Platelet-Derived Growth Factor Signaling Modulates Adult Hair Follicle Dermal Stem Cell Maintenance and Self-Renewal

37 citations, April 2017 in “npj Regenerative Medicine”

PDGF signaling is crucial for maintaining and renewing hair follicle stem cells, which could help treat hair loss.

research Dual Growth Factor Releasing Multi-Functional Nanofibers for Wound Healing

355 citations, August 2013 in “Acta Biomaterialia”

The nanofibers with two growth factors improved wound healing by supporting structure, preventing infection, and aiding tissue growth.

research 26SCS-Loaded SilMA/Col Composite Sponge with Well-Arranged Layers Promotes Angiogenesis-Based Diabetic Wound Repair by Mediating Macrophage Inflammatory Response

April 2024 in “Molecules/Molecules online/Molecules annual”

The composite sponge helps heal diabetic wounds by reducing inflammation and promoting new blood vessel growth.

research The Impact of Growth Factors in Platelet-Rich Plasma Combination Therapy for Androgenic Alopecia

January 2024 in “Dermatologic Therapy”

PRP therapy with specific growth factors improves hair density and thickness in androgenic alopecia.

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community Seriously confused about minoxidil's method of action

in Minoxidil 6 upvotes 2 years ago

The conversation discusses confusion about how Minoxidil promotes hair growth compared to other substances like Menthol, which have similar actions. The user mentions personal positive results with peppermint oil extract and is currently trying L-citrulline for its vasodilation effects.

community 2 years later I managed to gain some ground (Hyperresponder)

in Progress Pictures 43 upvotes 1 year ago

The user regained most of their hair using Minoxidil, Finasteride, and Dermarolling. They found Dermarolling particularly effective, as it promotes growth factors and improves hair thickness.

community Surprisingly thorough study on He-Shou-Wu/Fo Ti

in Research/Science 14 upvotes 1 year ago

He Shou Wu (Fo Ti) extract was found to prolong the hair growth phase, inhibit 5-alpha-reductase (like finasteride), reduce androgen receptors, and increase growth factors, potentially outperforming minoxidil in recovering hair follicle size after DHT exposure. Two compounds, emodin and TSG, are identified as responsible for these effects and warrant further investigation.

community Comprehensive Microneedling Guide

in Microneedling 295 upvotes 2 years ago

Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.