TLDR PDGF signaling is crucial for maintaining and renewing hair follicle stem cells, which could help treat hair loss.
The study from April 14, 2017, investigated the importance of Platelet-Derived Growth Factor (PDGF) signaling in the maintenance and self-renewal of hair follicle dermal stem cells (hfDSCs) in adult mice and its effects on human skin-derived precursors (SKPs). The researchers found that the deletion of the Pdgfra gene in mice led to a significant reduction in hfDSCs and their progeny, indicating that PDGF signaling is essential for hfDSC proliferation. In vitro experiments showed that PDGF-BB could enhance the proliferation of isolated hfDSCs and SKPs, increase the frequency of Sox2-positive hfDSC progeny, and improve the inductive capacity of hfDSCs to form hair follicles. The study, which involved n = 3 independent experiments from three different groups of mice and data from four adult human samples, suggests that PDGF signaling is critical for maintaining the hfDSC pool and could have therapeutic implications for hair loss conditions.
184 citations,
November 2014 in “Developmental Cell” Hair follicle dermal stem cells are key for regenerating parts of the hair follicle and determining hair type.
[object Object] 
211 citations,
April 2013 in “Development” More dermal papilla cells in hair follicles lead to larger, healthier hair, while fewer cells cause hair thinning and loss.
305 citations,
June 2012 in “Nature” Hair regeneration needs dynamic cell behavior and mesenchyme presence for stem cell activation.
499 citations,
September 2011 in “Cell” Fat-related cells are important for initiating hair growth.
330 citations,
December 2009 in “Cell stem cell” SKPs are similar to adult skin stem cells and could help in skin repair and hair growth.
9 citations,
August 2018 in “Biomedical dermatology” A peptide called DPS-1 helps human scalp cells grow and stimulates hair growth in mice.
26 citations,
July 2016 in “PLOS ONE” Activating β-catenin in certain skin cells speeds up hair growth in mice.
[object Object] 
10 citations,
February 2016 in “Journal of Dermatological Science” Skin sheath cells help in hair growth and renewal after birth.
184 citations,
November 2014 in “Developmental Cell” Hair follicle dermal stem cells are key for regenerating parts of the hair follicle and determining hair type.
154 citations,
October 1996 in “Proceedings of the National Academy of Sciences of the United States of America” Estrogen affects hair growth and skin cell multiplication.
