Expression Profiles of Tyrosine Kinases in Cultured Follicular Papilla Cells Versus Dermal Fibroblasts

    July 2004 in “ Journal of Investigative Dermatology ”
    Dawen Yu, Qiong Cao, Zhijun He, Tung‐Tien Sun
    TLDR Certain tyrosine kinases may regulate hair growth and could help develop hair loss treatments.
    The study analyzed the expression profiles of tyrosine kinases in cultured rat and human follicular papilla (FP) cells compared to dermal fibroblasts. It found that c-met, cdc2, and tec were preferentially expressed in FP cells, while α-platelet-derived growth factor receptor (α-PDGFR) was more prevalent in fibroblasts. Hepatocyte growth factor (HGF) stimulated FP cell growth, whereas PDGF-AA stimulated fibroblast growth. These findings suggested that specific tyrosine kinases might play roles in regulating hair growth and cycling, highlighting their potential importance in hair follicle regulation and implications for understanding hair follicle biology and developing treatments for hair loss.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 12 results

      community Beating gyno symptoms on fin: my recent success

      in Update  17 upvotes 3 years ago
      A user successfully managed finasteride-induced gyno symptoms by making lifestyle changes, including fasting, avoiding soy, and increasing cardio. They resumed finasteride with a lower dose combined with minoxidil and P7 vitamins without recurrence of symptoms.

      community I'm tired, boss. I fought. Now I seem to be losing.

      in Update  21 upvotes 2 years ago
      The user is struggling with hair loss despite using finasteride, minoxidil, and ketoconazole, and addressing vitamin D and ferritin deficiencies. They experienced a temporary improvement but are now shedding hair again and feeling stressed.

      community 25 years on finasteride - my experience

      in Finasteride/Dutasteride  943 upvotes 7 months ago
      A long-term finasteride user experienced side effects like sexual dysfunction, dry eyes, muscle weakness, and brain fog, which improved when they stopped the medication. They decided to stop finasteride again, questioning if maintaining hair was worth the negative impact on their well-being.

      community Ultimate Stack without nuking your gender (you'll go broke)

      in Treatment  84 upvotes 8 months ago
      A hair loss treatment plan includes finasteride, dutasteride, RU58841, pyrilutamide, minoxidil, and microneedling to inhibit DHT and promote hair growth. It also recommends supplements like Reishi and Lion’s Mane mushrooms, and a shampoo with ketoconazole, caffeine, and melatonin.

    Similar Research

    5 / 1000+ results