Expression Profiles of Tyrosine Kinases in Cultured Follicular Papilla Cells Versus Dermal Fibroblasts

    July 2004 in “ Journal of Investigative Dermatology ”
    Dawen Yu, Qiong Cao, Zhijun He, Tung‐Tien Sun
    TLDR Certain tyrosine kinases may regulate hair growth and could help develop hair loss treatments.
    The study analyzed the expression profiles of tyrosine kinases in cultured rat and human follicular papilla (FP) cells compared to dermal fibroblasts. It found that c-met, cdc2, and tec were preferentially expressed in FP cells, while α-platelet-derived growth factor receptor (α-PDGFR) was more prevalent in fibroblasts. Hepatocyte growth factor (HGF) stimulated FP cell growth, whereas PDGF-AA stimulated fibroblast growth. These findings suggested that specific tyrosine kinases might play roles in regulating hair growth and cycling, highlighting their potential importance in hair follicle regulation and implications for understanding hair follicle biology and developing treatments for hair loss.
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