Osteopontin Gene Is Expressed in the Dermal Papilla of Pelage Follicles in a Hair-Cycle-Dependent Manner

December 2001 in “ Journal of Investigative Dermatology ”

Da Wen Yu, Tian Yang, Tadashige Sonoda, Yanling Gong, Qiong Cao, Kevin J. Gaffney, Pamela J. Jensen, Irwin M. Freedberg, Robert M. Lavker, Tung-Tien Sun

osteopontin OPN dermal papilla catagen phase anagen phase telogen phase extracellular matrix protein cell attachment signaling tissue survival apoptosis androgen androgenic alopecia OPN mRNA vibrissa dermal papilla cells skin fibroblasts hair cycle hair disorders hair diseases

Studysummary This study found that osteopontin mRNA is abundantly expressed in dermal papilla cells during the catagen phase of hair growth in rats, suggesting a role in this phase. Our plain-language summary of this paper — not a Tressless recommendation.

The 2001 study found that the osteopontin (OPN) gene is expressed in the dermal papilla of rat pelage follicles specifically during the catagen phase of the hair cycle, but not during the anagen or telogen phases. OPN, an extracellular matrix protein, may play a role in cell attachment, signaling, and tissue survival, and could be involved in the aggregation of dermal papilla cells or protection against apoptosis during catagen. The study also noted that androgen suppresses OPN expression, which could be relevant to hair diseases like androgenic alopecia. The research involved comparing OPN mRNA levels in cultured rat vibrissa dermal papilla cells, which were high, to those in cultured rat skin fibroblasts, where OPN mRNA was not detected. This study enhances the understanding of hair cycle regulation and the potential mechanisms underlying hair disorders.

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Research cited in this study

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Androgen Receptors Are Only Present in Mesenchyme-Derived Dermal Papilla Cells of Red Deer Neck Follicles When Raised Androgens Induce a Mane in the Breeding Season

research Androgen Receptors Are Only Present in Mesenchyme-Derived Dermal Papilla Cells of Red Deer Neck Follicles When Raised Androgens Induce a Mane in the Breeding Season

24 citations , March 2001 in “Journal of Endocrinology/Journal of endocrinology”

In this study, androgen receptors were found only in the mane follicles of red deer stags during the breeding season, suggesting their expression is induced by seasonal hormone changes.

research Differences in Hair Follicle Dermal Papilla Volume Are Due to Extracellular Matrix Volume and Cell Number: Implications for the Control of Hair Follicle Size and Androgen Responses

231 citations , December 1999 in “Journal of Investigative Dermatology”

This study found that the volume of a hair follicle's dermal papilla is strongly correlated with its size, primarily due to the number of cells it contains and the volume of extracellular matrix.

research The mRNA for Protease Nexin-1 is Expressed in Human Dermal Papilla Cells and its Level is Affected by Androgen

27 citations , September 1999 in “Journal of Investigative Dermatology”

This study found that protease nexin-1 mRNA is expressed in human dermal papilla cells and is downregulated by dihydrotestosterone in balding scalp, suggesting a role in male-pattern baldness progression.

research Reduction of Intrafollicular Apoptosis in Chemotherapy-Induced Alopecia by Topical Calcitriol Analogs

53 citations , October 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that cyclophosphamide induced significant keratinocyte apoptosis in anagen hair follicles of mice, while topical calcitriol-analogs reduced this apoptosis, suggesting a protective effect against chemotherapy-induced alopecia.

research 5α-Reductase Activity in the Human Hair Follicle Concentrates in the Dermal Papilla

41 citations , March 1998 in “Archives of Dermatological Research”

This study found that androgen metabolism within hair follicles varies significantly between compartments, with dermal papillae showing high 5α-reductase activity, suggesting a key role in androgen-driven hair growth responses.

research Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp

227 citations , January 1998 in “Journal of Endocrinology”

This study found that dermal papilla cells from balding scalp hair follicles have significantly higher levels of androgen receptors than those from non-balding follicles, supporting their in vivo androgen response.

Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque

research Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque

33 citations , January 1997 in “Endocrinology”

Testosterone was found to inhibit hair follicle epithelial cell proliferation in adult stumptailed macaques only when dermal papilla cells from bald scalps were present, and this effect was reversed by the antiandrogen RU 58841.

research Ability to Culture Dermal Papilla Cells from Red Deer Hair Follicles with Differing Hormonal Responses In Vivo Offers a New Model for Studying the Control of Hair Follicle Biology

16 citations , August 1996 in “The journal of experimental zoology/Journal of experimental zoology”

This study suggests that red deer stags provide a novel model for investigating hormonal regulation of hair growth due to the different cell growth rates in hair follicles during breeding and nonbreeding seasons.

research A Comparison of the Culture and Growth of Dermal Papilla Cells from Hair Follicles from Non-Balding and Balding (Androgenetic Alopecia) Scalp

30 citations , March 1996 in “British Journal of Dermatology”

research Message of Nexin 1, a Serine Protease Inhibitor, Accumulates in the Follicular Papilla During Anagen of the Hair Cycle

37 citations , December 1995 in “Journal of Cell Science”

This study found that nexin 1 mRNA, a potent protease inhibitor, is prevalent in rat follicular papilla cells and may play a role in regulating hair follicular growth.

research Induction of Follicle Formation and Hair Growth by Vibrissa Dermal Papillae Implanted into Rat Ear Wounds: Vibrissa-Type Fibres Are Specified

125 citations , August 1992 in “Development”

This study found that implanting isolated adult rat dermal papillae into ear cuts led to the emergence of unusually large vibrissa-type hair follicles, demonstrating their capacity to induce specific hair fiber characteristics.