Optimal Stimulation Toward the Dermal Papilla Lineage Can Be Promoted by Combined Use of Osteogenic and Adipogenic Inducers

November 2019 in “ FEBS open bio ”

Taheruzzaman Kazi, Ichitaro Niibe, Akio Nishikawa, Takashi Matsuzaki

osteogenic inducers adipogenic inducers FGF2 PDGF-AA dermal papilla cells DPCs hair follicle development hair growth dermal papilla markers spheroid structure hair-forming activity alopecia fibroblast growth factor 2 platelet-derived growth factor-AA hair loss

TLDR Combining specific inducers helps dermal papilla cells regain hair-forming ability.

The study concluded that the combined use of osteogenic and adipogenic inducers, along with FGF2 and PDGF-AA, significantly promoted the optimal stimulation of dermal papilla cells (DPCs) toward the dermal papilla lineage, which is essential for hair follicle development and hair growth. This combination enhanced the expression of key dermal papilla markers, maintained spheroid structure, and improved hair-forming activity in vitro and in grafted nude mice. The findings suggested a potential therapeutic approach for hair loss and alopecia by effectively targeting and preserving the hair-regenerative properties of DPCs.

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