Bee Venom Stimulates Growth Factor Release from Adipose-Derived Stem Cells to Promote Hair Growth

February 2024 in “ Toxins ”

Jung-Hyun Kim, Tae Yoon Kim, Bonhyuk Goo, Yeon-Cheol Park

Studysummary This study found that bee venom accelerated the transition from the telogen to anagen phase in mice, increasing hair growth by day 14, and suggested that bee venom may enhance adipose-derived stem cell activity by upregulating growth factor secretion.

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The study investigates the potential of bee venom (BV) to stimulate hair growth through adipose-derived stem cells (ASCs). BV was found to be non-toxic to ASCs at concentrations up to 2500 ng/mL. Pretreatment of ASCs with BV significantly promoted hair growth in mice, as evidenced by increased hair follicle development and Ki67+ cell proliferation. BV also enhanced ASC migration and angiogenesis in vitro. Additionally, BV increased the expression of growth factors such as PDGF-C, ECGF, FGF-1, FGF-6, and ALP, which are crucial for hair follicle activity and the anagen phase. The study further demonstrated that BV activates the ERK pathway in ASCs, suggesting a mechanism for its effects. These findings indicate that BV can effectively promote hair growth by enhancing ASC function and growth factor release.

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