A Systematic Review of Keratinocyte Secretions: A Regenerative Perspective

    July 2022 in “ International Journal of Molecular Sciences ”
    Ahmed T. El‐Serafi, Ibrahim El-Serafi, Ingrid Steinvall, Folke Sjöberg, Moustafa Elmasry
    Image of study
    TLDR Skin cells release substances important for healing and fighting infection, and understanding these could improve skin disorder treatments.
    The systematic review analyzed 100 references and identified 80 different secretions from keratinocytes, the predominant cell type in the skin's outermost layer. These secretions, mainly cytokines, growth factors, and antimicrobial peptides, play a crucial role in skin regeneration and stem cell differentiation into keratinocytes. The most frequently mentioned secretion was Interleukin (IL) 8, found in 39 studies, followed by IL-6 and tumor necrosis factor, each found in 15 studies. These cytokines establish the appropriate inflammatory condition to combat infection and enhance cell differentiation and wound healing. The review also emphasized the need for further investigation to characterize these secretions and evaluate their regenerative capacities. The study suggests that further characterization of keratinocyte secretions could lead to the development of effective treatments for skin disorders and wound repair.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 22 results

      community Comprehensive Microneedling Guide

      in Microneedling  290 upvotes 2 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

      community Sandalore: a scientific homemade approch

       20 upvotes 6 years ago
      The post discusses using Sandalore as a potential hair loss treatment, emphasizing precise measurements and safe handling. The user compares Sandalore's effects to Minoxidil and mentions preparing a solution with ethanol and DMSO.

      community Minoxidil Sulfate makes everyone a responder

      in Research/Science  255 upvotes 1 month ago
      Minoxidil sulfate is more effective than regular minoxidil, especially for those with low sulfotransferase levels or scalp sensitivity, but it is unstable unless delivered in a liposomal format. Combining minoxidil with tretinoin can enhance effectiveness, and stopping minoxidil use can lead to rapid hair loss.

      community AGA responded to steroid shots? Biopsy wrong? Please help!

      in Female  2 upvotes 7 months ago
      A woman with AGA is using spironolactone, dutasteride, finasteride, oral minoxidil, bicalutamide, and anti-androgenic birth control but still experiences worsening hair loss. Steroid shots temporarily stop her hair shedding, leading her to question her biopsy results.

    Similar Research

    5 / 1000+ results