Keratinocyte Biology And Pathology

August 2014 in “ Veterinary Dermatology ”

Eliane J. Müller, Arnaud Galichet, Dominique J. Wiener, Eliane Marti, Cord Drögemüller, Monika Welle, Petra Roosje, Tosso Leeb, Maja M. Suter

keratinocyte epidermis homeostasis immune response sensory functions epigenetic regulation molecular alterations atopic dermatitis self-renewal hair follicles hair follicle disorders regenerative medicine

TLDR Keratinocytes play a key role in skin health, but more research is needed.

The document reviewed the advancements in understanding keratinocyte biology and pathology, highlighting the evolution of knowledge since the 1990s. It emphasized the epidermis as a complex organ involved in homeostasis, immune response, and sensory functions. The study at the University of Bern contributed to identifying new control mechanisms, such as epigenetic regulation, and molecular alterations in dogs with atopic dermatitis. The research also explored the self-renewal capacity of keratinocytes and hair follicles, which has implications for hair follicle disorders and regenerative medicine. Despite significant progress, the authors acknowledged that much remains to be discovered in this field.