TLDR Keratinocytes play a key role in skin health, but more research is needed.
The document reviewed the advancements in understanding keratinocyte biology and pathology, highlighting the evolution of knowledge since the 1990s. It emphasized the epidermis as a complex organ involved in homeostasis, immune response, and sensory functions. The study at the University of Bern contributed to identifying new control mechanisms, such as epigenetic regulation, and molecular alterations in dogs with atopic dermatitis. The research also explored the self-renewal capacity of keratinocytes and hair follicles, which has implications for hair follicle disorders and regenerative medicine. Despite significant progress, the authors acknowledged that much remains to be discovered in this field.
28 citations
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May 2012 in “Veterinary Dermatology” Different types of dog hair loss are linked to problems starting the hair growth phase and early hair cycle ending.
508 citations
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February 2007 in “Cell” Epithelial stem cells are crucial for tissue renewal and repair, and understanding them could improve treatments for damage and cancer.
73 citations
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August 2019 in “Cell Proliferation” Human skin models are essential for studying skin's sensory, immune, and nervous system interactions.
1 citations
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January 2016 in “Elsevier eBooks” The document concludes that a complete skin restoration biomaterial does not yet exist, and more clinical trials are needed to ensure these therapies are safe and effective.
50 citations
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April 2021 in “Frontiers in Immunology” New therapies targeting skin neuroimmune interactions could treat neuropathic pain.
124 citations
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December 2016 in “Pharmaceuticals” TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.
69 citations
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June 2017 in “Experimental Biology and Medicine” Advanced human skin models improve drug development and could replace animal testing.
