This review explores the mechanisms of adult stem cell self-renewal, using skin as a model, and reports no new results but raises important unanswered questions in the field.
April 2018 in “Journal of Investigative Dermatology”
This study reports that in aged mice, hair follicle dermal stem cells exhibit diminished self-renewal and preferential differentiation into dermal sheath cells, contributing to age-related hair loss.
This study found that PDGFA is critical for the proliferation and maintenance of adipocyte stem cells in skin but not other white adipose tissues, highlighting unique regulatory mechanisms in different tissue depots.
16 citations
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August 2022 in “Nature Communications”
In this study, researchers discovered that ROR2, a Wnt receptor, plays a crucial role in regulating hair follicle stem cell self-renewal and maintenance, compensating for the absence of β-catenin.
PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.
Doctors in Denmark and other countries often lack knowledge about hair loss treatments like Finasteride and Dutasteride, causing patients to seek prescriptions from multiple doctors or online. Some users report better experiences in countries like Brazil and Korea, where doctors are more informed and willing to prescribe these medications.
Dutasteride takes 1-3 months to affect scalp DHT levels, not just a week. The prostate absorbs Dutasteride faster than the scalp due to different vascular networks and enzyme densities.
Creatine may increase DHT levels, potentially affecting hair loss in some individuals, but opinions vary. Some users report hair loss while on creatine, while others see no effect, especially when using treatments like finasteride, minoxidil, and microneedling.
The user is using topical minoxidil and finasteride, along with daily derma rolling, and is considering using an organic self-tanner on their shaved scalp. They seek advice on whether the self-tanner's ingredients could harm hair regrowth.