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    Glossary Self-Renewal

    process where stem cells divide to produce identical stem cells

    Self-renewal is the process by which stem cells divide to produce more stem cells, maintaining their undifferentiated state. This ability is crucial for tissue regeneration and repair, as it ensures a continuous supply of stem cells that can differentiate into various cell types needed for growth and healing.

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    1. A matter of life and death: self‐renewal in stem cells EMBO Reports · 2012 · 150 citations
    2. 1314 Advanced age impairs self-renewal and biases fate choice of hair follicle dermal stem cells Journal of Investigative Dermatology · 2018
    3. Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis Cell Stem Cell · 2016 · 106 citations
    4. OCT4 maintains self-renewal and reverses senescence in human hair follicle mesenchymal stem cells through the downregulation of p21 by DNA methyltransferases Stem Cell Research & Therapy · 2019 · 57 citations
    5. ROR2 regulates self-renewal and maintenance of hair follicle stem cells Nature Communications · 2022 · 16 citations
    6. 653 Substance P ameliorates epidermal thickness, basal cell density, and asymmetric stem cell self-renewal in skin with decreased sensory innervation Journal of Investigative Dermatology · 2024
    7. Regulation of self-renewal in colorectal cancer cell models Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya) · 2014
    8. Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury Cell Reports · 2023 · 46 citations
    9. Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury bioRxiv (Cold Spring Harbor Laboratory) · 2023 · 2 citations
    10. ZO-1 boosts the in vitro self-renewal of pre-haematopoietic stem cells from OCT4-reprogrammed human hair follicle mesenchymal stem cells through cytoskeleton remodeling Stem Cell Research & Therapy · 2024
    11. A stretch-responsive fibroblast program promotes epidermal stem cell self-renewal during skin expansion Nature Communications · 2026
    12. 1405 Cellular and molecular characterization of sebaceous gland self-renewal and regeneration following complete genetic ablation Journal of Investigative Dermatology · 2023
    13. Platelet-derived growth factor signaling modulates adult hair follicle dermal stem cell maintenance and self-renewal npj Regenerative Medicine · 2017 · 37 citations
    14. Ectopic Expression of the nude Gene Induces Hyperproliferation and Defects in Differentiation: Implications for the Self-Renewal of Cutaneous Epithelia Developmental biology · 1999 · 69 citations
    15. Dab2 (Disabled-2), an adaptor protein, regulates self-renewal of hair follicle stem cells Communications Biology · 2024 · 1 citations
    16. Long-term renewal of hair follicles from clonogenic multipotent stem cells Proceedings of the National Academy of Sciences of the United States of America · 2005 · 291 citations
    17. Hair follicle stem cell cultures reveal self‐organizing plasticity of stem cells and their progeny The EMBO Journal · 2016 · 61 citations
    18. Dedifferentiation of committed epithelial cells into stem cells in vivo Nature · 2013 · 551 citations
    19. Isolation of a Novel Population of Multipotent Adult Stem Cells from Human Hair Follicles American Journal Of Pathology · 2006 · 344 citations
    20. Adipose‐Derived Stem Cells for Tissue Engineering and Regenerative Medicine Applications Stem Cells International · 2016 · 294 citations
    21. Epidermal stem cell diversity and quiescence EMBO molecular medicine · 2009 · 168 citations
    22. The Harmonies Played by TGF-β in Stem Cell Biology Cell Stem Cell · 2012 · 156 citations
    23. Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties Nature cell biology · 2017 · 143 citations
    24. Human skin stem cells and the ageing process Experimental gerontology · 2008 · 143 citations
    25. TGF-β family signaling in stem cells Biochimica et Biophysica Acta (BBA) - General Subjects · 2012 · 132 citations
    26. Normal stem cells and cancer stem cells: similar and different Seminars in Cancer Biology · 2010 · 126 citations
    27. Human Epidermal Neural Crest Stem Cells (hEPI-NCSC)—Characterization and Directed Differentiation into Osteocytes and Melanocytes Stem Cell Reviews and Reports · 2011 · 91 citations
    28. Extracellular Matrix as a Regulator of Epidermal Stem Cell Fate International Journal of Molecular Sciences · 2018 · 57 citations
    29. Maintenance of high proliferation and multipotent potential of human hair follicle-derived mesenchymal stem cells by growth factors International Journal of Molecular Medicine · 2013 · 56 citations
    30. Isolation of epithelial stem cells from dermis by a three-dimensional culture system Journal of Cellular Biochemistry · 2006 · 38 citations