From Basic Biology to Engineered Therapies: The Keratinocyte Stem Cell Playbook

    February 2026 in “ Frontiers in Medical Technology ”
    Adnan Uddin, Mohamad Rahmani, Abdulrahim A. Sajini
    Studysummary This review discusses current knowledge of keratinocyte stem cell dynamics, including their regenerative roles and potential applications beyond wound healing, but presents no new clinical findings.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 11

    1. YAP/TAZ Signaling Controls Epidermal Keratinocyte Fate International Journal of Molecular Sciences · 2024
    2. The Empowering Influence of Air-Liquid Interface Culture on Skin Organoid Hair Follicle Development Burns & Trauma · 2024
    3. Bioengineered Skin Organoids: From Development to Applications Military Medical Research · 2023
    4. Current Status of Cell-Based Therapies for Vitiligo International Journal of Molecular Sciences · 2023
    5. Progress in Studies of Epidermal Stem Cells and Their Application in Skin Tissue Engineering Stem Cell Research & Therapy · 2020
    6. Epidermal Stem Cells in Wound Healing and Their Clinical Applications Stem Cell Research & Therapy · 2019
    7. Integrin Signaling Regulates YAP/TAZ to Control Skin Homeostasis Development · 2016
    8. Anatomy and Function of the Skin Elsevier eBooks · 2016
    9. Two- And Three-Dimensional Culture Of Keratinocyte Stem And Precursor Cells Derived From Primary Murine Epidermal Cultures Stem Cell Reviews and Reports · 2011
    10. Long-Term Renewal of Hair Follicles from Clonogenic Multipotent Stem Cells Proceedings of the National Academy of Sciences of the United States of America · 2005
    11. A Simple In Vivo System for Studying Epithelialization, Hair Follicle Formation, and Invasion Using Primary Epidermal Cells from Wild-Type and Transgenic Ornithine Decarboxylase-Overexpressing Mouse Skin Journal of Investigative Dermatology · 2001