Integrin Signaling Regulates YAP/TAZ to Control Skin Homeostasis

    January 2016 in “ Development ”
    Ahmed Elbediwy, Zoé I. Vincent‐Mistiaen, Bradley Spencer‐Dene, Richard Stone, Stefan Boeing, Stefanie K. Wculek, J. Cordero, Ee Hong Tan, Randall Ridgway, Valerie G. Brunton, Erik Sahai, Holger Gerhardt, Axel Behrens, Ilaria Malanchi, Owen J. Sansom, Barry J. Thompson
    Studysummary In this study, researchers found that YAP and TAZ, when localized in the nucleus of basal layer cells, are crucial for skin regeneration and hair growth, with their loss leading to slower cell proliferation, hair loss, and impaired wound healing in mice. Our plain-language summary of this paper — not a Tressless recommendation.
    The study demonstrated that the transcription regulators YAP and TAZ were essential for maintaining skin homeostasis by promoting the proliferation of basal layer stem/progenitor cells. In both mouse and human skin, YAP and TAZ localized in the nucleus of basal layer cells, regulated by integrin-Src signaling. Deletion of YAP and TAZ in mice resulted in slowed cell proliferation, hair loss, and impaired wound healing, underscoring their role in skin regeneration. The research highlighted the importance of integrin-Src and EGFR-PI3K signaling pathways for YAP nuclear localization, which was crucial for cell cycle progression and growth. Additionally, YAP acted as a sensor of epithelial cell polarity, with its localization influenced by apical-basal polarity signals. These findings provided insights into the molecular mechanisms of skin renewal and the potential impact of YAP and TAZ on skin-related conditions and cancer.
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