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Glossary Dedifferentiation

process where mature cells revert to a primitive state

Dedifferentiation is a biological process where specialized, mature cells revert to a more primitive, unspecialized state. This can occur in response to injury or stress and is significant in regenerative medicine and cancer research, as it can lead to tissue repair or, conversely, uncontrolled cell growth.

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research Dedifferentiation of committed epithelial cells into stem cells in vivo

551 citations , November 2013 in “Nature”

This study found that differentiated airway epithelial cells can revert into functional stem cells in vivo, suggesting a more general role for this dedifferentiation process in tissue regeneration in higher vertebrates.

research Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties

143 citations , May 2017 in “Nature cell biology”

This study found that the transcription factor Gata6 regulates the sebaceous duct lineage identity and plays a crucial role in epidermal wound healing by enabling dedifferentiation and broader lineage capabilities in post-mitotic cells.

research Dermal adipose tissue has high plasticity and undergoes reversible dedifferentiation in mice

136 citations , September 2019 in “Journal of Clinical Investigation”

This study found that mature dermal adipocytes have high plasticity, undergoing dedifferentiation and redifferentiation, which plays a significant role in hair cycling and wound healing.

research Differentiation of Mouse Induced Pluripotent Stem Cells into a Multipotent Keratinocyte Lineage

101 citations , December 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study reports the successful differentiation of mouse induced pluripotent stem cells into keratinocytes that can regenerate skin and its structures in an in vivo environment.

research Differentiation of the sebaceous gland

60 citations , March 2009 in “Dermato-Endocrinology”

This review highlights recent findings on the importance of signalling pathways in sebaceous gland morphogenesis and differentiation, but reports no new clinical results.

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community Dosage Advice for Finasteride and Differentiating Side Effects at 22

in Basic Questions 54 upvotes 1 month ago

A 22-year-old is considering taking 1mg finasteride and 2.5mg minoxidil orally every other day to address low hair density while minimizing mental side effects. They seek advice on distinguishing between drug-related side effects and personal life issues.

community Looking for clarification on Section 8 of the Comprehensive Microneedling Guide

3 upvotes 1 year ago

The conversation discusses the steps for microneedling, specifically differentiating between medical needling (0.5-1.5mm) and cosmetic needling (0.3mm). It emphasizes the importance of cleaning and disinfecting before microneedling, regardless of needle length.

community Minoxidil Response Bottlenecks: Why Sulfation and Transport Matter (And Where Tretinoin Fits In)

in Research 461 upvotes 1 year ago

Minoxidil's effectiveness is limited by the need for sulfation and proper transport to hair follicles, with tretinoin potentially enhancing its effects by promoting enzyme activity and keratinocyte differentiation. Tretinoin may improve minoxidil's response by boosting the expression of necessary enzymes and transporters.

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