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    Glossary Dedifferentiation

    process where mature cells revert to a primitive state

    Dedifferentiation is a biological process where specialized, mature cells revert to a more primitive, unspecialized state. This can occur in response to injury or stress and is significant in regenerative medicine and cancer research, as it can lead to tissue repair or, conversely, uncontrolled cell growth.

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    Research 10 of 1000+

    1. Dedifferentiation of committed epithelial cells into stem cells in vivo Nature · 2013 · 551 citations
    2. Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties Nature cell biology · 2017 · 143 citations
    3. Dermal adipose tissue has high plasticity and undergoes reversible dedifferentiation in mice Journal of Clinical Investigation · 2019 · 136 citations
    4. Differentiation of Mouse Induced Pluripotent Stem Cells into a Multipotent Keratinocyte Lineage 2010 · 101 citations
    5. Differentiation of the sebaceous gland Dermato-Endocrinology · 2009 · 60 citations
    6. Specific morphogenetic events in mouse external genitalia sex differentiation are responsive/dependent upon androgens and/or estrogens Differentiation · 2012 · 51 citations
    7. Hair follicle differentiation‐specific keratin expression in human basal cell carcinoma Clinical and Experimental Dermatology · 2019 · 45 citations
    8. Eph/ephrin signaling in epidermal differentiation and disease Seminars in Cell & Developmental Biology · 2011 · 42 citations
    9. Endocrine controls of primary adult human stem cell biology: Thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro European Journal of Cell Biology · 2010 · 42 citations
    10. Dissection of a Complex Enhancer Element: Maintenance of Keratinocyte Specificity but Loss of Differentiation Specificity Molecular and Cellular Biology · 2002 · 42 citations
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    Community 4 of 5

    1. Dosage Advice for Finasteride and Differentiating Side Effects at 22 Community · 17 Aug 2026
    2. Minoxidil Response Bottlenecks: Why Sulfation and Transport Matter (And Where Tretinoin Fits In) Community · 11 Jun 2025
    3. Sunlight: Does it Stimulate Hair Growth or Hair Loss? Reddit · 9 Apr 2024
    4. NMN Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress Reddit · 9 Jun 2024
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